Literature DB >> 6095127

Inhibitory effect of thyroid hormones on pituitary cyclic amp phosphodiesterase activity in vitro.

A Nagasaka, H Hidaka, K Kataoka, K Iwase, H Nakagawa, A Nakai, T Aono, T Ohyama.   

Abstract

Thyroid hormones effectively inhibited partially purified cyclic AMP phosphodiesterase from the anterior and posterior lobes of bovine pituitary gland competitively with the substrate, but thyronine, diiodotyrosine, monoiodotyrosine, thyrotropin, thyrotropin releasing hormone, dexamethasone, and luteinizing hormone releasing hormone did not inhibit this enzyme activity. Ki values were found to be 1.0 and 2.5 microM for thyroxine, and 8.0 and 13.5 microM for triiodothyronine in the anterior and posterior lobes, respectively.

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Year:  1984        PMID： 6095127     DOI： 10.1007/bf00964530

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  20 in total

1.  TRH and prostaglandin action on rat anterior pituitary: dissociation between cyclic AMP levels and TSH release.

Authors:  E Tal; M Szabo; G Burke
Journal:  Prostaglandins       Date:  1974-01-25

2.  A new assay of cyclic nucleotide phosphodiesterase; its application to human serum.

Authors:  H Hidaka; M Shibuya
Journal:  Biochem Med       Date:  1974-08

3.  Inhibition of adenosine 3',5'-monophosphate accumulation in anterior pituitary gland in vitro by growth hormone-release inhibiting hormone.

Authors:  P Borgeat; F Labrie; J Drouin; A Bélanger; H Immer; K Sestanj; V Nelson; M Götz; A V Schally; D H Coy; E J Coy
Journal:  Biochem Biophys Res Commun       Date:  1974-02-27       Impact factor: 3.575

4.  Thyrotropin release in vitro: stimulation by cyclic 3',5'-Adenosine monophosphate.

Authors:  J F Wilber; G T Peake; R D Utiger
Journal:  Endocrinology       Date:  1969-04       Impact factor: 4.736

5.  Lipolytic action of 3,3'5-triiodo-L-thyronine, a cyclic AMP phosphodiesterase inhibitor.

Authors:  L R Mandel; F A Kuehl
Journal:  Biochem Biophys Res Commun       Date:  1967-07-10       Impact factor: 3.575

6.  Stimulation of mitochondrial protein synthesis and oxygen consumption by thyroxine in vitro without deiodination to triiodothyronine.

Authors:  M P Primack; D F Tapley; J Buchanan
Journal:  Biochim Biophys Acta       Date:  1971-08-19

7.  A possible role of cyclic AMP in mediating the effects of thyrotropin-releasing hormone on prolactin release and on prolactin and growth hormone synthesis in pituitary cells in culture.

Authors:  P S Dannies; K M Gautvik; A H Tashjian
Journal:  Endocrinology       Date:  1976-05       Impact factor: 4.736

8.  3':5'-cyclic-nucleotide phosphodiesterase in the bovine pituitary gland.

Authors:  A Nagasaka; S Ohkubo; H Hidaka
Journal:  Biochim Biophys Acta       Date:  1983-02-22

9.  Human thyroid cyclic nucleotide phosphodiesterase. Its characterization and the effect of several hormones on the activity.

Authors:  A Nagasaka; H Hidaka
Journal:  Biochim Biophys Acta       Date:  1976-07-08

10.  Phosphodiesterase activity in human subcutaneous adipose tissue in hyper- and hypothyroidism.

Authors:  P Engfeldt; P Arner; J Bolinder; A Wennlund; J Ostman
Journal:  J Clin Endocrinol Metab       Date:  1982-03       Impact factor: 5.958
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