Literature DB >> 6095109

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.

A L Schechter, D F Stern, L Vaidyanathan, S J Decker, J A Drebin, M I Greene, R A Weinberg.   

Abstract

A series of rat neuro/glioblastomas all contain the same transforming gene (neu) which induces synthesis of a tumour antigen of relative molecular mass (Mr) 185,000 (p185). The neu oncogene bears homology to erb-B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

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Year:  1984        PMID： 6095109     DOI： 10.1038/312513a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  264 in total

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