Literature DB >> 6094934

Naloxone inhibits the plasma epinephrine response to ACTH but not to 2-deoxy-D-glucose in rats.

T Okajima, S Ikuyama, K Kato, H Ibayashi.   

Abstract

Intravenous injection of (1-24) ACTH and 2-deoxy-d-glucose (2DG) stimulated the plasma epinephrine and norepinephrine levels in pentobarbital-anesthetized male rats. Naloxone, a specific opiate antagonist, inhibited the plasma epinephrine response to ACTH but not to 2DG. Norepinephrine release induced by ACTH or 2DG was not affected by naloxone. These results suggest that the opioid peptidergic synapse might be involved in the ACTH- but not in the 2DG-induced epinephrine release.

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Year:  1984        PMID: 6094934     DOI: 10.1016/0024-3205(84)90457-0

Source DB:  PubMed          Journal:  Life Sci        ISSN: 0024-3205            Impact factor:   5.037


  3 in total

1.  Reversal of scopolamine-induced amnesia of passive avoidance by pre- and post-training naloxone.

Authors:  D K Rush
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Involvement of the sympathetic nervous system in the cardiovascular effects of ACTH-(1-24) during hemorrhagic shock in rats.

Authors:  S Guarini; W Ferrari; A Bertolini
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-05       Impact factor: 3.000

3.  ACTH increases noradrenaline release in the rabbit heart.

Authors:  B Szabo; L Hedler; C Schurr; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-10       Impact factor: 3.000

  3 in total

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