Literature DB >> 6094430

Cefotaxime in the cerebrospinal fluid and serum in patients with purulent meningitis.

P Peretti, L Sueri, M Tosi, R Ciammarughi, G P Cadeo, B Milanesi.   

Abstract

Cefotaxime concentrations in the cerebrospinal fluid and serum were determined in patients with purulent meningitis by means of a simple, rapid and reproducible method in agar medium. The CSF concentrations of cefotaxime fluctuated around 4 mg/l. The pharmacokinetics of the antibiotic in relation to the integrity of the blood-brain barrier was studied by means of an assay of the albumin and IgG present in the cerebrospinal fluid and in the serum.

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Year:  1984        PMID： 6094430     DOI： 10.1093/jac/14.suppl_b.117

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  7 in total

1.  Penetration of Cefotaxime into Cerebrospinal Fluid in Neonates and Young Infants.

Authors:  Xing-Kai Chen; Hai-Yan Shi; Stephanie Leroux; Hai-Yan Xu; Yue Zhou; Yi Zheng; Xin Huang; Yan Li; Evelyne Jacqz-Aigrain; Wei Zhao
Journal:  Antimicrob Agents Chemother       Date:  2018-03-27       Impact factor: 5.191

2.  Cefotaxime breakpoint for Streptococcus pneumoniae.

Authors:  E Cantón
Journal:  Antimicrob Agents Chemother       Date:  1993-03       Impact factor: 5.191

Review 3.  Cefotaxime. An update of its pharmacology and therapeutic use.

Authors:  P A Todd; R N Brogden
Journal:  Drugs       Date:  1990-10       Impact factor: 9.546

Review 4.  Cefotaxime. A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections.

Authors:  R N Brogden; C M Spencer
Journal:  Drugs       Date:  1997-03       Impact factor: 9.546

5.  Relationship of MICs to efficacy of cefotaxime in treatment of Streptococcus pneumoniae infections.

Authors:  R F Jacobs; S L Kaplan; G E Schutze; A S Dajani; R J Leggiadro; C S Rim; S K Puri
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

6.  Passage of cefotaxime and ceftriaxone into cerebrospinal fluid of patients with uninflamed meninges.

Authors:  R Nau; H W Prange; P Muth; G Mahr; S Menck; H Kolenda; F Sörgel
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

7.  Meningitis due to a multiply resistant pneumococcus.

Authors:  D J Waghorn
Journal:  J R Soc Med       Date:  1992-02       Impact factor: 18.000
  7 in total

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