| Literature DB >> 6094424 |
P H Chandrasekar, K V Rolston, B R Smith, J L LeFrock.
Abstract
Fourteen adults, three recovering from bacterial meningitis, were given a single 2 g dose of ceftriaxone or three 2 g doses at 12-hourly intervals. The mean per cent penetration of drug into cerebrospinal fluid (CSF) across uninflamed meninges was 1.5%. These levels, although low, are bactericidal in vitro against most pathogens causing meningitis.Entities:
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Year: 1984 PMID： 6094424 DOI： 10.1093/jac/14.4.427
Source DB: PubMed Journal: J Antimicrob Chemother ISSN： 0305-7453 Impact factor: 5.790