Literature DB >> 6094251

Thiyl free radical production with hematoporphyrin derivative, cysteine and light: a spin-trapping study.

G R Buettner.   

Abstract

Hematoporphyrin derivative, used in photodynamic therapy of cancer, was found to generate the cysteinyl free radical as seen by spin-trapping. Oxygen appears to be an absolute requirement for thiyl radical production. Singlet oxygen may be the initiating species since azide inhibits oxygen uptake and radical production. In addition, the hydroxyl radical, or a radical with similar reactivity, is also observed and is proposed as the precursor for thiyl free radical production.

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Year:  1984        PMID： 6094251     DOI： 10.1016/0014-5793(84)81303-4

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  Induction of an antioxidant protein of Saccharomyces cerevisiae by O2, Fe3+, or 2-mercaptoethanol.

Authors:  I H Kim; K Kim; S G Rhee
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

Review 2.  Oxidative risk for atherothrombotic cardiovascular disease.

Authors:  Jane A Leopold; Joseph Loscalzo
Journal:  Free Radic Biol Med       Date:  2009-09-12       Impact factor: 7.376

3.  Combination toxicity of etoposide (VP-16) and photosensitisation with a water-soluble aluminium phthalocyanine in K562 human leukaemic cells.

Authors:  T G Gantchev; N Brasseur; J E van Lier
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

4.  Biochemical screening for SARS-CoV-2 main protease inhibitors.

Authors:  Camila Coelho; Gloria Gallo; Claudia B Campos; Leon Hardy; Martin Würtele
Journal:  PLoS One       Date:  2020-10-06       Impact factor: 3.240
  4 in total

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