Literature DB >> 6094250

Heme a induces assembly of rat liver cytochrome c oxidase subunits I--III in isolated mitochondria.

A Wielburski, B D Nelson.   

Abstract

The assembly of cytochrome c oxidase subunits I-III was studied in vitro in isolated rat liver mitochondria pre-labeled with [35S]methionine. Individual subunits were immunoabsorbed with monospecific antibodies. Isolated heme a from rat liver mitochondria, when added to radiolabeled mitochondria, induced assembly of subunit I with subunits II and III. Assembly of these subunits was not observed in mitochondria incubated in the presence of heme b(hemin) or in the absence of heme. Quantitative analysis of immunoabsorbed, radiolabeled subunits suggests that the predominant effect of heme a is on the assembly of subunit I with subunit III.

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Year:  1984        PMID： 6094250     DOI： 10.1016/0014-5793(84)81302-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Decreased activity of cytochrome c oxidase in the macular mottled mouse: an immuno-electron microscopic study.

Authors:  K Seki; T Sato; Y Ishigaki; S Nakamura; Y Ishihara; T Ozawa
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

2.  Human cytochrome c oxidase during cardiac growth and development.

Authors:  J Marin-Garcia; L S Baskin
Journal:  Pediatr Cardiol       Date:  1989       Impact factor: 1.655

3.  A role for heme in Alzheimer's disease: heme binds amyloid beta and has altered metabolism.

Authors:  Hani Atamna; William H Frey
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-19       Impact factor: 11.205

4.  Definition of the catalytic site of cytochrome c oxidase: specific ligands of heme a and the heme a3-CuB center.

Authors:  J P Shapleigh; J P Hosler; M M Tecklenburg; Y Kim; G T Babcock; R B Gennis; S Ferguson-Miller
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

5.  Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis.

Authors:  Yu Fukuda; Yao Wang; Shangli Lian; John Lynch; Shinjiro Nagai; Bruce Fanshawe; Ayten Kandilci; Laura J Janke; Geoffrey Neale; Yiping Fan; Brian P Sorrentino; Martine F Roussel; Gerard Grosveld; John D Schuetz
Journal:  JCI Insight       Date:  2017-08-03

6.  Inhibition of heme synthesis alters Amyloid Precursor Protein processing.

Authors:  Luisa Benerini Gatta; Massimiliano Vitali; Rosanna Verardi; Paolo Arosio; Dario Finazzi
Journal:  J Neural Transm (Vienna)       Date:  2008-11-11       Impact factor: 3.575

7.  Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.

Authors:  Osamu Hori; Fusae Ichinoda; Takashi Tamatani; Atsushi Yamaguchi; Naoya Sato; Kentaro Ozawa; Yasuko Kitao; Mayuki Miyazaki; Heather P Harding; David Ron; Masaya Tohyama; David M Stern; Satoshi Ogawa
Journal:  J Cell Biol       Date:  2002-06-24       Impact factor: 10.539
  7 in total

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