Literature DB >> 6094240

Glyceraldehyde, but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+.

C B Wollheim, S Ullrich, T Pozzan.   

Abstract

The dynamics of changes in membrane potential, cytosolic free Ca2+, [Ca2+]i and immunoreactive insulin release were assessed in RINm5F cells. Membrane depolarization and a rise in [Ca2+]i preceded the stimulation of insulin release by D-glyceraldehyde. Forskolin, which raised the cellular cyclic AMP levels, stimulated insulin release without changing membrane potential or [Ca2+]i. It is concluded that cyclic AMP acts on insulin release not by mobilizing Ca2+ but by another, as yet undefined, mechanism.

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Year:  1984        PMID： 6094240     DOI： 10.1016/0014-5793(84)80972-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Distinct mechanisms for two amplification systems of insulin release.

Authors:  J C Henquin; M Bozem; W Schmeer; M Nenquin
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

2.  ATP-sensitive K+ channels in an insulin-secreting cell line are inhibited by D-glyceraldehyde and activated by membrane permeabilization.

Authors:  M J Dunne; I Findlay; O H Petersen; C B Wollheim
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

3.  Different insulin-secretory responses to calcium-channel blockers in islets of lean and obese (ob/ob) mice.

Authors:  M A Black; L A Fournier; H M Heick; N Bégin-Heick
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

4.  Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.

Authors:  P Arkhammar; A Hallberg; H Kindmark; T Nilsson; P Rorsman; P O Berggren
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

5.  Effects of propylthiouracil and methylthiouracil on cyclic AMP and ion movements in rat pancreatic islets.

Authors:  M Mark; E Fitzel; N Youssif; A B Müller; M I Anazodo; H P Ammon
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-02       Impact factor: 3.000

6.  Cyclic adenosine monophosphate differently affects the response of mouse pancreatic beta-cells to various amino acids.

Authors:  J C Henquin; H P Meissner
Journal:  J Physiol       Date:  1986-12       Impact factor: 5.182

7.  Potentiation of stimulus-induced insulin secretion in protein kinase C-deficient RINm5F cells.

Authors:  G D Li; R Regazzi; S Ullrich; W F Pralong; C B Wollheim
Journal:  Biochem J       Date:  1990-12-15       Impact factor: 3.857

8.  Effects of caffeine on cytoplasmic free Ca2+ concentration in pancreatic beta-cells are mediated by interaction with ATP-sensitive K+ channels and L-type voltage-gated Ca2+ channels but not the ryanodine receptor.

Authors:  M S Islam; O Larsson; T Nilsson; P O Berggren
Journal:  Biochem J       Date:  1995-03-15       Impact factor: 3.857

9.  A possible role for glyceraldehyde transport in the stimulation of HIT-T15 insulinoma cells.

Authors:  J Davies; S Tomlinson; A C Elliott; L Best
Journal:  Biochem J       Date:  1994-11-15       Impact factor: 3.857

10.  Dynamics of insulin release by perifused insulin-producing tumoral cells: effects of glucose, forskolin, leucine, barium and theophylline.

Authors:  V Leclercq-Meyer; M H Giroix; A Sener; J Marchand; W J Malaisse
Journal:  Int J Pancreatol       Date:  1988 Jan-Feb
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