Literature DB >> 6094234

Forskolin suppresses seizures induced by pentylenetetrazol in mice.

M Sano, A Seto-Ohshima, A Mizutani.   

Abstract

Forskolin, an adenylate cyclase activator when injected s.c. (1 mg/kg) in mice, caused an elevation of cAMP in the forebrain and cerebellum of up to 170% and 130%, respectively. The treatment was found to prevent seizures induced by pentylenetetrazol. This suppression had subsided 30 min after the injection, when cAMP level was again normal in the cerebellum but still elevated in the forebrain.

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Year:  1984        PMID： 6094234     DOI： 10.1007/bf01946669

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  13 in total

1.  Metabolite levels in brain following experimental seizures: the effects of maximal electroshock and phenytoin in cerebellar layers.

Authors:  D W McCandless; G K Feussner; W D Lust; J V Passonneau
Journal:  J Neurochem       Date:  1979-03       Impact factor: 5.372

2.  Cyclic 3',5'-adenosine monophosphate in mouse cerebral cortex during homocysteine convulsions and their prevention by sodium phenobarbital.

Authors:  J Folbergrová
Journal:  Brain Res       Date:  1975-07-04       Impact factor: 3.252

3.  Cyclic nucleotides in murine brain: the temporal relationship of changes induced in adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate following maximal electroshock or decapitation.

Authors:  W D Lust; N D Goldberg; J V Passonneau
Journal:  J Neurochem       Date:  1976-01       Impact factor: 5.372

4.  Convenient elimination of trichloroacetic acid prior to radioimmunoassay of cyclic nucleotides.

Authors:  C Tihon; M B Goren; E Spitz; H V Rickenberg
Journal:  Anal Biochem       Date:  1977-06       Impact factor: 3.365

5.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

6.  Changes of cyclic AMP and phosphorylase a in mouse cerebral cortex during seizures induced by 3-mercaptopropionic acid.

Authors:  J Folbergrová
Journal:  Brain Res       Date:  1977-10-28       Impact factor: 3.252

7.  Forskolin as a novel lipolytic agent.

Authors:  R Ho; Q H Shi
Journal:  Biochem Biophys Res Commun       Date:  1982-07-16       Impact factor: 3.575

8.  Activation of cyclic AMP-generating systems in brain membranes and slices by the diterpene forskolin: augmentation of receptor-mediated responses.

Authors:  J W Daly; W Padgett; K B Seamon
Journal:  J Neurochem       Date:  1982-02       Impact factor: 5.372

9.  Adenylate cyclase activation shifts the phase of a circadian pacemaker.

Authors:  A Eskin; J S Takahashi
Journal:  Science       Date:  1983-04-01       Impact factor: 47.728

10.  Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

Authors:  K B Seamon; W Padgett; J W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
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  6 in total

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Review 2.  Synaptic Vesicle-Recycling Machinery Components as Potential Therapeutic Targets.

Authors:  Ying C Li; Ege T Kavalali
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3.  Effects of forskolin and cyclic nucleotides in animal models predictive of antidepressant activity: interactions with rolipram.

Authors:  H Wachtel; P A Löschmann
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Disruption of polycystin-L causes hippocampal and thalamocortical hyperexcitability.

Authors:  Gang Yao; Chong Luo; Michael Harvey; Maoqing Wu; Taylor H Schreiber; Yanjun Du; Nuria Basora; Xuefeng Su; Diego Contreras; Jing Zhou
Journal:  Hum Mol Genet       Date:  2015-11-26       Impact factor: 6.150

5.  Anticonvulsant Activity of Extracts of Plectranthus barbatus Leaves in Mice.

Authors:  Luciana Cristina Borges Fernandes; Carlos Campos Câmara; Benito Soto-Blanco
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-09       Impact factor: 2.629

6.  Long-term in vivo application of a potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus.

Authors:  P Kleis; E Paschen; U Häussler; Y A Bernal Sierra; C A Haas
Journal:  BMC Biol       Date:  2022-01-14       Impact factor: 7.431
  6 in total

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