Literature DB >> 6093808

Pertussis toxin inhibits the rise in the intracellular concentration of free calcium that is induced by chemotactic factors in rabbit neutrophils: possible role of the "G proteins" in calcium mobilization.

T F Molski, P H Naccache, M L Marsh, J Kermode, E L Becker, R I Sha'afi.   

Abstract

The addition of pertussis toxin to rabbit neutrophils inhibits the rise in the intracellular concentration of free calcium induced by the chemotactic factors fMet-Leu-Phe and leukotriene B4. At high concentrations of fMet-Leu-Phe, the inhibitory effect of the toxin is more on the stimulus-induced increase in membrane permeability to calcium than on calcium mobilization from internal stores. These results suggest that the "G protein" system either directly or indirectly is involved in the regulation of the stimulus-induced changes in the calcium mobilization and/or gating systems.

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Year:  1984        PMID： 6093808     DOI： 10.1016/0006-291x(84)91603-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  37 in total

1.  Dual regulation of neutrophil adenylate cyclase by fluoride and its relationship to cellular activation.

Authors:  M Saad; C F Strnad; K Wong
Journal:  Br J Pharmacol       Date:  1987-08       Impact factor: 8.739

Review 2.  Mechanisms of calcium homeostasis in the polymorphonuclear leucocyte.

Authors:  J Westwick; C Poll
Journal:  Agents Actions       Date:  1986-10

3.  Evidence that activation of a common G-protein by receptors for leukotriene B4 and N-formylmethionyl-leucyl-phenylalanine in HL-60 cells occurs by different mechanisms.

Authors:  K R McLeish; P Gierschik; T Schepers; D Sidiropoulos; K H Jakobs
Journal:  Biochem J       Date:  1989-06-01       Impact factor: 3.857

4.  Inositol 1,4,5-triphosphate-induced granule secretion in platelets. Evidence that the activation of phospholipase C mediated by platelet thromboxane receptors involves a guanine nucleotide binding protein-dependent mechanism distinct from that of thrombin.

Authors:  L F Brass; C C Shaller; E J Belmonte
Journal:  J Clin Invest       Date:  1987-04       Impact factor: 14.808

5.  Cholera toxin inhibits chemotaxis by a cAMP-independent mechanism.

Authors:  R R Aksamit; P S Backlund; G L Cantoni
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

6.  Diminished agonist-stimulated inositol trisphosphate generation blocks stimulus-secretion coupling in mouse pancreatic acini during diet-induced experimental pancreatitis.

Authors:  R E Powers; A K Saluja; M J Houlihan; M L Steer
Journal:  J Clin Invest       Date:  1986-05       Impact factor: 14.808

7.  Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

Authors:  S J Brandt; R W Dougherty; E G Lapetina; J E Niedel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

8.  Up-regulation of phospholipid hydroperoxide glutathione peroxidase in rat casein-induced polymorphonuclear neutrophils.

Authors:  Hiroyuki Hattori; Hirotaka Imai; Akiharu Hanamoto; Kazuhisa Furuhama; Yasuhito Nakagawa
Journal:  Biochem J       Date:  2005-07-15       Impact factor: 3.857

Review 9.  Leukotriene B4 and platelet-activating factor in human skin.

Authors:  L Michel; L Dubertret
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017

10.  Activation of the human neutrophil 5-lipoxygenase by leukotriene B4.

Authors:  P P McDonald; S R McColl; P H Naccache; P Borgeat
Journal:  Br J Pharmacol       Date:  1992-09       Impact factor: 8.739
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