Literature DB >> 6093776

Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle.

M C Sekar, B D Roufogalis.   

Abstract

Muscarinic-receptor stimulation by 0.1 mM-carbachol in longitudinal muscle of the guinea-pig ileum increases the incorporation of [3H]inositol into inositol-containing phospholipid. This effect was blocked by 16 microM-atropine. After 60 min incubation, carbachol increased the accumulation of total inositol phosphates 20-fold in the presence of 10 mM-Li+. Less than 20% of the total inositol phosphate corresponded to inositol 1-phosphate by ion-exchange chromatography, whereas of the remainder about two-thirds corresponded to inositol bisphosphate and one third to inositol trisphosphate. It is concluded that stimulation of muscarinic receptors in guinea-pig ileum enhances breakdown of polyphosphoinositides, suggesting that this may be a primary event associated with Ca2+ mobilization in the guinea-pig ileum.

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Year:  1984        PMID： 6093776      PMCID： PMC1144327          DOI： 10.1042/bj2230527

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  30 in total

1.  Cholinergic stimulation of polyphosphoinositide metabolism in brain in vivo.

Authors:  J F Soukup; R O Friedel; S M Schanberg
Journal:  Biochem Pharmacol       Date:  1978       Impact factor: 5.858

Review 2.  Inositol phospholipids and cell surface receptor function.

Authors:  R H Michell
Journal:  Biochim Biophys Acta       Date:  1975-03-25

3.  Inhibition of the effect of lithium on brain inositol by atropine and scopolamine.

Authors:  J H Allison; M E Blisner
Journal:  Biochem Biophys Res Commun       Date:  1976-02-23       Impact factor: 3.575

4.  Erythrocyte membrane polyphosphoinositide metabolism and the regulation of calcium binding.

Authors:  J T Buckley; J N Hawthorne
Journal:  J Biol Chem       Date:  1972-11-25       Impact factor: 5.157

5.  Quantitative aspects of drug-receptor interactions. I. Ca2+ and cholinergic receptor activation in smooth muscle: a basic model for drug-receptor interactions.

Authors:  K J Chang; D J Triggle
Journal:  J Theor Biol       Date:  1973-07       Impact factor: 2.691

Review 6.  The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions.

Authors:  R H Michell; C J Kirk; L M Jones; C P Downes; J A Creba
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1981-12-18       Impact factor: 6.237

7.  Alteration of smooth muscle contractility after muscarinic agonist-induced K+ loss.

Authors:  M R James-Kracke; B D Roufogalis
Journal:  Br J Pharmacol       Date:  1981-04       Impact factor: 8.739

8.  Muscarinic cholinergic stimulation of phosphatidylinositol turnover in the longitudinal smooth muscle of guinea-pig ileum.

Authors:  S S Jafferji; R H Michell
Journal:  Biochem J       Date:  1976-03-15       Impact factor: 3.857

9.  The polyphosphoinositide phosphodiesterase of erythrocyte membranes.

Authors:  C P Downes; R H Michell
Journal:  Biochem J       Date:  1981-07-15       Impact factor: 3.857

10.  Evidence that lithium alters phosphoinositide metabolism: chronic administration elevates primarily D-myo-inositol-1-phosphate in cerebral cortex of the rat.

Authors:  W R Sherman; A L Leavitt; M P Honchar; L M Hallcher; B E Phillips
Journal:  J Neurochem       Date:  1981-06       Impact factor: 5.372
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  10 in total

1.  Short-term desensitization of guinea-pig taenia caecum induced by carbachol occurs at intracellular Ca stores and that by histamine at H1-receptors.

Authors:  S Hishinuma; M K Uchida
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

Review 2.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

3.  Combined phosphoinositide and Ca2+ signals mediating receptor specificity toward neuronal Ca2+ channels.

Authors:  Oleg Zaika; Jie Zhang; Mark S Shapiro
Journal:  J Biol Chem       Date:  2010-11-04       Impact factor: 5.157

4.  Activation of muscarinic receptors in PC12 cells. Stimulation of Ca2+ influx and redistribution.

Authors:  T Pozzan; F Di Virgilio; L M Vicentini; J Meldolesi
Journal:  Biochem J       Date:  1986-03-15       Impact factor: 3.857

5.  Depolarisation of guinea-pig visceral smooth muscle causes hydrolysis of inositol phospholipids.

Authors:  L Best; T B Bolton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1986-05       Impact factor: 3.000

6.  Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

Authors:  H U Simon; G B Mills; S Hashimoto; K A Siminovitch
Journal:  J Clin Invest       Date:  1992-10       Impact factor: 14.808

7.  Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction.

Authors:  T von Schrenck; B Mackensen; U Mende; W Schmitz; J Sievers; S Mirau; A Raedler; H Greten
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-04       Impact factor: 3.000

8.  Relationship between stimulated phosphatidic acid production and inositol lipid hydrolysis in intestinal longitudinal smooth muscle from guinea pig.

Authors:  R S Mallows; T B Bolton
Journal:  Biochem J       Date:  1987-06-15       Impact factor: 3.857

9.  Comparison of the effects of some muscarinic agonists on smooth muscle function and phosphatidylinositol turnover in the guinea-pig taenia caeci.

Authors:  A L Gardner; L K Choo; F Mitchelson
Journal:  Br J Pharmacol       Date:  1988-05       Impact factor: 8.739

10.  Positive inotropic effects induced by carbachol in rat atria treated with islet-activating protein (IAP)--association with phosphatidylinositol breakdown.

Authors:  S Imai; H Ohta
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
  10 in total

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