Literature DB >> 6093766

Pertussis toxin blocks the inhibitory effect of muscarinic cholinergic agonists on cyclic AMP accumulation and prolactin secretion in GH3 anterior-pituitary tumour cells.

B L Brown, R J Wojcikiewicz, P R Dobson, A Robinson, L I Irons.   

Abstract

The inhibition of prolactin secretion and cyclic AMP accumulation in GH3 cells by muscarinic agonists was blocked by preincubation of the cells with pertussis toxin (islet-activating protein). There was a lag of approx. 80 min in the onset of the effect on secretion. These results suggest that muscarinic agonists decrease prolactin secretion by inhibiting adenylate cyclase activity.

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Year:  1984        PMID： 6093766      PMCID： PMC1144274          DOI： 10.1042/bj2230145

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  21 in total

Review 1.  Thyrotropin releasing hormone. A review of the mechanisms of acute stimulation of pituitary hormone release.

Authors:  M C Gershengorn
Journal:  Mol Cell Biochem       Date:  1982-06-25       Impact factor: 3.396

2.  Calcium rather than cyclic AMP as the physiological intracellular regulator of prolactin release.

Authors:  M O Thorner; J T Hackett; F Murad; R M MacLeod
Journal:  Neuroendocrinology       Date:  1980-12       Impact factor: 4.914

3.  Slow interaction of islet-activating protein with pancreatic islets during primary culture to cause reversal of alpha-adrenergic inhibition of insulin secretion.

Authors:  T Katada; M Ui
Journal:  J Biol Chem       Date:  1980-10-25       Impact factor: 5.157

4.  Muscarinic inhibition of prolactin production in cultures of rat pituitary cells.

Authors:  M S Rudnick; P S Dannies
Journal:  Biochem Biophys Res Commun       Date:  1981-07-30       Impact factor: 3.575

5.  Acetylcholine receptors in the rat anterior pituitary gland.

Authors:  J M Schaeffer; A J Hsueh
Journal:  Endocrinology       Date:  1980-05       Impact factor: 4.736

6.  Femtomole sensitive radioimmunoassay for cyclic AMP and cyclic GMP after 2'0 acetylation by acetic anhydride in aqueous solution.

Authors:  J F Harper; G Brooker
Journal:  J Cyclic Nucleotide Res       Date:  1975

7.  Acetylcholine stimulates growth hormone secretion, phosphatidyl inositol labelling, 45Ca2+ efflux and cyclic GMP accumulation in bovine anterior pituitary glands.

Authors:  P W Young; R J Bicknell; J G Schofield
Journal:  J Endocrinol       Date:  1979-02       Impact factor: 4.286

8.  Studies on the control and dynamics of thyrotropin secretion from isolated adenohypophyseal cells.

Authors:  M P Schrey; B L Brown; R P Ekins
Journal:  Mol Cell Endocrinol       Date:  1977-10       Impact factor: 4.102

9.  Muscarinic receptor binding in sheep anterior pituitary.

Authors:  D R Burt; R L Taylor
Journal:  Neuroendocrinology       Date:  1980-06       Impact factor: 4.914

10.  Islet-activating protein. A modifier of receptor-mediated regulation of rat islet adenylate cyclase.

Authors:  T Katada; M Ui
Journal:  J Biol Chem       Date:  1981-08-25       Impact factor: 5.157
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  5 in total

1.  The relationship between pertussis-toxin-induced ADP-ribosylation of a plasma-membrane protein and reversal of muscarinic inhibition of prolactin secretion in GH3 cells.

Authors:  R J Wojcikiewicz; P R Dobson; L I Irons; A Robinson; B L Brown
Journal:  Biochem J       Date:  1984-11-15       Impact factor: 3.857

2.  Thyroliberin action in pituitary cells is not inhibited by pertussis toxin.

Authors:  P M Hinkle; E L Hewlett; M C Gershengorn
Journal:  Biochem J       Date:  1986-07-01       Impact factor: 3.857

3.  Measurement of intracellular mediators in enterocytes isolated from jejunal biopsy specimens of control and cystic fibrosis patients.

Authors:  B W Hitchin; P R Dobson; B L Brown; J Hardcastle; P T Hardcastle; C J Taylor
Journal:  Gut       Date:  1991-08       Impact factor: 23.059

4.  Limited accumulation of cyclic AMP underlies a modest vasoactive-intestinal-peptide-mediated increase in cytosolic [Ca2+] transients in GH3 pituitary cells.

Authors:  P Mollard; Y Zhang; D Rodman; D M Cooper
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

5.  Regulation of GH3 pituitary tumour-cell adenylate cyclase activity by activators of protein kinase C.

Authors:  L A Quilliam; P R Dobson; B L Brown
Journal:  Biochem J       Date:  1989-09-15       Impact factor: 3.857
  5 in total

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