Literature DB >> 6093012

Nicotinic transmission in sympathetic ganglia: blockade by the snake venom neurotoxin kappa-bungarotoxin.

V A Chiappinelli, S E Dryer.   

Abstract

Kappa-bungarotoxin, a snake venom alpha-neurotoxin, blocks nicotinic transmission in chick lumbar sympathetic ganglia as well as in the rat superior cervical ganglion. Intracellular and extracellular recordings support the conclusion that the toxin has a specific action at the postsynaptic nicotinic receptors on ganglia neurons. The affinity of kappa-bungarotoxin for receptors in chick ganglia appears to be higher than that for receptors in the rat ganglia. Kappa-bungarotoxin can thus be used as a ligand for studying nicotinic receptors in a variety of neuronal preparations.

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Year:  1984        PMID： 6093012     DOI： 10.1016/0304-3940(84)90492-0

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

Review 1.  Protein complexes in snake venom.

Authors:  R Doley; R M Kini
Journal:  Cell Mol Life Sci       Date:  2009-06-04       Impact factor: 9.261

2.  Rapid synaptic transmission in the avian ciliary ganglion is mediated by two distinct classes of nicotinic receptors.

Authors:  E M Ullian; J M McIntosh; P B Sargent
Journal:  J Neurosci       Date:  1997-10-01       Impact factor: 6.167

3.  Neural nicotinic acetylcholine responses in solitary mammalian retinal ganglion cells.

Authors:  S A Lipton; E Aizenman; R H Loring
Journal:  Pflugers Arch       Date:  1987-09       Impact factor: 3.657

4.  The sensitivity of nicotinic synapses in bullfrog sympathetic ganglia to alpha-bungarotoxin and neuronal-bungarotoxin.

Authors:  W X Shen; P Jobling; J P Horn
Journal:  Br J Pharmacol       Date:  1994-11       Impact factor: 8.739

5.  Pharmacology of nicotinic receptor-mediated inhibition in rat dorsolateral septal neurones.

Authors:  L A Wong; J P Gallagher
Journal:  J Physiol       Date:  1991-05       Impact factor: 5.182

Review 6.  Cholinergic activity as a new target in diseases of the heart.

Authors:  Ashbeel Roy; Silvia Guatimosim; Vania F Prado; Robert Gros; Marco A M Prado
Journal:  Mol Med       Date:  2015-01-26       Impact factor: 6.354
  6 in total

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