Literature DB >> 6092727

Characterization of cellular sequences flanking an integrated bovine leukemia virus genome.

E P Gelmann, A Burny, R Kettmann.   

Abstract

We cloned a 20.2-kilobase fragment, including the unique proviral integration site, from the tumor tissue DNA of a bovine leukemia virus-induced lymphoma (tumor 1351). This clone contained 5.5 kilobases of flanking sequences at either side of the full-length integrated viral genome. Hybridization analysis of both 3' and 5' cellular flanking regions provided no evidence for rearrangements at this locus in other tumors, RNA transcription from either flanking region, or homology to eight known onc genes.

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Year:  1984        PMID： 6092727      PMCID： PMC254626     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  11 in total

1.  Experiments with cloned complete tumor-derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species.

Authors:  J Deschamps; R Kettmann; A Burny
Journal:  J Virol       Date:  1981-11       Impact factor: 5.103

2.  Restriction endonuclease mapping of linear unintegrated proviral DNA of bovine leukemia virus.

Authors:  R Kettmann; D Couez; A Burny
Journal:  J Virol       Date:  1981-04       Impact factor: 5.103

3.  Different bovine leukemia virus-induced tumors harbor the provirus in different chromosomes.

Authors:  D Grégoire; D Couez; J Deschamps; S Heuertz; M C Hors-Cayla; J Szpirer; C Szpirer; A Burny; G Huez; R Kettmann
Journal:  J Virol       Date:  1984-04       Impact factor: 5.103

4.  Lack of expression of cellular homologues of retroviral onc genes in bovine tumors.

Authors:  R Kettmann; E H Westin; G Marbaix; J Deschamps; F Wong-Staal; R C Gallo; A Burny
Journal:  Haematol Blood Transfus       Date:  1983

5.  Leukemogenesis by bovine leukemia virus: proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3' proximate cellular sequences.

Authors:  R Kettmann; J Deschamps; Y Cleuter; D Couez; A Burny; G Marbaix
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

6.  Genomic integration of bovine leukemia provirus: comparison of persistent lymphocytosis with lymph node tumor form of enzootic.

Authors:  R Kettmann; Y Cleuter; M Mammerickx; M Meunier-Rotival; G Bernardi; A Burny; H Chantrenne
Journal:  Proc Natl Acad Sci U S A       Date:  1980-05       Impact factor: 11.205

7.  Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

Authors:  P Gunning; P Ponte; H Okayama; J Engel; H Blau; L Kedes
Journal:  Mol Cell Biol       Date:  1983-05       Impact factor: 4.272

8.  Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15.

Authors:  R Nusse; A van Ooyen; D Cox; Y K Fung; H Varmus
Journal:  Nature       Date:  1984 Jan 12-18       Impact factor: 49.962

9.  Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA.

Authors:  M Seiki; S Hattori; Y Hirayama; M Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

10.  Chromosome integration domain for bovine leukemia provirus in tumors.

Authors:  R Kettmann; J Deschamps; D Couez; J J Claustriaux; R Palm; A Burny
Journal:  J Virol       Date:  1983-07       Impact factor: 5.103
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