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Literature DB >> 6092064

Analysis of the gene coding for the murine cellular tumour antigen p53.

B Bienz, R Zakut-Houri, D Givol, M Oren.

Abstract

A genomic clone containing the functional gene for the murine p53 cellular tumour antigen was isolated and structurally characterised. The gene contains at least 11 exons and 10 introns, the first intron possessing a length of 6.1 kb. Attempts to determine the exact 5' end of p53 mRNA were inconclusive, probably due to the presence of a remarkable stem and loop structure (delta G degrees approximately equal to -56 kcal/mol) in the 5' region of the gene. Suggestive similarities were found to exist between p53 and the protein product of the myc oncogene.

Entities: Chemical

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Year: 1984 PMID： 6092064 PMCID： PMC557662 DOI： 10.1002/j.1460-2075.1984.tb02110.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

31 in total

1. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors: A J Berk; P A Sharp
Journal: Cell Date: 1977-11 Impact factor: 41.582

2. Screening lambdagt recombinant clones by hybridization to single plaques in situ.

Authors: W D Benton; R W Davis
Journal: Science Date: 1977-04-08 Impact factor: 47.728

3. Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus.

Authors: P Donner; I Greiser-Wilke; K Moelling
Journal: Nature Date: 1982-03-18 Impact factor: 49.962

4. SV40-53K antigen: a possible role for 53K in normal cells.

Authors: J Milner; S Milner
Journal: Virology Date: 1981-07-30 Impact factor: 3.616

5. The relationship between the SV40 genome and viral mRNA.

Authors: S M Weissman
Journal: Mol Cell Biochem Date: 1981-02-26 Impact factor: 3.396

6. The myc oncogene in man and birds.

Authors: R Weiss
Journal: Nature Date: 1982-09-02 Impact factor: 49.962

Review 7. Organization and expression of eucaryotic split genes coding for proteins.

Authors: R Breathnach; P Chambon
Journal: Annu Rev Biochem Date: 1981 Impact factor: 23.643

8. The isolation of structural genes from libraries of eucaryotic DNA.

Authors: T Maniatis; R C Hardison; E Lacy; J Lauer; C O'Connell; D Quon; G K Sim; A Efstratiadis
Journal: Cell Date: 1978-10 Impact factor: 41.582

9. Sequencing end-labeled DNA with base-specific chemical cleavages.

Authors: A M Maxam; W Gilbert
Journal: Methods Enzymol Date: 1980 Impact factor: 1.600

10. Influence of mRNA secondary structure on binding and migration of 40S ribosomal subunits.

Authors: M Kozak
Journal: Cell Date: 1980-01 Impact factor: 41.582

57 in total

1. Length and secondary structure of the 5' non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies.

Authors: Joanna Szpotkowska; Agata Swiatkowska; Jerzy Ciesiołka
Journal: RNA Biol Date: 2018-12-20 Impact factor: 4.652

2. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.

Authors: P Hinds; C Finlay; A J Levine
Journal: J Virol Date: 1989-02 Impact factor: 5.103

3. Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment.

Authors: O Halevy; A Hall; M Oren
Journal: Mol Cell Biol Date: 1989-08 Impact factor: 4.272

Analysis of the gene coding for the murine cellular tumour antigen p53.

1. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

2. Screening lambdagt recombinant clones by hybridization to single plaques in situ.

3. Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus.

4. SV40-53K antigen: a possible role for 53K in normal cells.

5. The relationship between the SV40 genome and viral mRNA.

6. The myc oncogene in man and birds.

Review 7. Organization and expression of eucaryotic split genes coding for proteins.

8. The isolation of structural genes from libraries of eucaryotic DNA.

9. Sequencing end-labeled DNA with base-specific chemical cleavages.

10. Influence of mRNA secondary structure on binding and migration of 40S ribosomal subunits.

1. Length and secondary structure of the 5' non-coding regions of mouse p53 mRNA transcripts - mouse as a model organism for p53 gene expression studies.

2. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation.

3. Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment.

4. MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection.

5. E1A oncogene induction of cytolytic susceptibility eliminates sarcoma cell tumorigenicity.

6. p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage.

7. The tumor suppressor p53 regulates its own transcription.

8. Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene.

9. Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.

10. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.