Literature DB >> 6091776

Changes in cytosolic free Ca2+ in isolated parietal cells. Differential effects of secretagogues.

S Muallem, G Sachs.   

Abstract

The relationship of free cytosolic Ca2+ to secretagogue-dependent activation of acid secretion by the mammalian parietal cell was studied using quin 2 as an intracellular Ca2+ probe. The resting [Ca2+]in of isolated dog parietal cells was found to be 134 +/- 11 nM. Carbachol produced a steady-state increase of [Ca2+]in and its effect was blocked by atropine and Ca2+ -channel blocking agents. Gastrin transiently elevated [Ca2+]in and this was not affected by Ca2+ -channel blocking agents. Neither histamine nor dbcAMP changed resting [Ca2+]in in rabbit parietal cells.

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Year:  1984        PMID： 6091776     DOI： 10.1016/0167-4889(84)90166-6

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  7 in total

1.  Ca2+-ATPase in mucous and oxyntico-peptic cells of the fowl proventriculus.

Authors:  A O Salem; M Kressin; B Schnorr
Journal:  Cell Tissue Res       Date:  1992-12       Impact factor: 5.249

Review 2.  Gastric H+,K(+)-ATPase as a therapeutic target in peptic ulcer disease.

Authors:  G Sachs; K Munson; K Hall; S J Hersey
Journal:  Dig Dis Sci       Date:  1990-12       Impact factor: 3.199

3.  Expression cloning and characterization of the canine parietal cell gastrin receptor.

Authors:  A S Kopin; Y M Lee; E W McBride; L J Miller; M Lu; H Y Lin; L F Kolakowski; M Beinborn
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

4.  Effect of gastric secretagogues on the formation of inositol phosphates in isolated gastric cells of the rat.

Authors:  J Puurunen; U Schwabe
Journal:  Br J Pharmacol       Date:  1987-03       Impact factor: 8.739

5.  Interactions between intracellular cyclic AMP and agonist-induced inositol phospholipid breakdown in isolated gastric mucosal cells of the rat.

Authors:  J Puurunen; M J Lohse; U Schwabe
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-11       Impact factor: 3.000

6.  Early signalling mechanism in colonic epithelial cell response to gastrin.

Authors:  R R Yassin; K M Little
Journal:  Biochem J       Date:  1995-11-01       Impact factor: 3.857

7.  Small synthetic ligands of the cholecystokinin-B/gastrin receptor can mimic the function of endogenous peptide hormones.

Authors:  M Beinborn; C Chen; L DeMeo; E W McBride; A S Kopin
Journal:  Yale J Biol Med       Date:  1998 May-Aug
  7 in total

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