Literature DB >> 6091759

Evidence that neutral sphingomyelinase of cultured murine neuroblastoma cells is oriented externally on the plasma membrane.

D V Das, H W Cook, M W Spence.   

Abstract

The activity of the neutral, Mg2+-stimulated sphingomyelinase of cultured neuroblastoma cells (N1E-115) is enriched in the plasma membrane fraction and is reduced following treatment of intact or broken cells with trypsin, alpha-chymotrypsin, papain, and protease. Two protease-sensitive enzymes of the cell interior (lactate dehydrogenase and NADPH-cytochrome c reductase) are not affected by protease treatment of intact cells. These results indicate that the neutral, Mg2+-stimulated sphingomyelinase is oriented externally on the plasma membrane of the cultured neuroblastoma cell.

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Year:  1984        PMID： 6091759     DOI： 10.1016/0005-2736(84)90437-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  11 in total

1.  Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids.

Authors:  B S Robinson; C S Hii; A Poulos; A Ferrante
Journal:  Immunology       Date:  1997-06       Impact factor: 7.397

2.  Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.

Authors:  K Hofmann; S Tomiuk; G Wolff; W Stoffel
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

Review 3.  Cell regulation by sphingosine and more complex sphingolipids.

Authors:  A H Merrill
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

4.  Sphingosine enhances platelet aggregation through an increase in phospholipase C activity by a protein kinase C-independent mechanism.

Authors:  T Hashizume; T Sato; T Fujii
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

5.  Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

Authors:  S L Schissel; J Tweedie-Hardman; J H Rapp; G Graham; K J Williams; I Tabas
Journal:  J Clin Invest       Date:  1996-09-15       Impact factor: 14.808

6.  Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts.

Authors:  N Andrieu; R Salvayre; T Levade
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

7.  TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB.

Authors:  Karen L Edelblum; Jeremy A Goettel; Tatsuki Koyama; Steven J McElroy; Fang Yan; D Brent Polk
Journal:  J Biol Chem       Date:  2008-08-18       Impact factor: 5.157

8.  Fluorescent, short-chain C6-NBD-sphingomyelin, but not C6-NBD-glucosylceramide, is subject to extensive degradation in the plasma membrane: implications for signal transduction related to cell differentiation.

Authors:  J W Kok; T Babia; K Klappe; D Hoekstra
Journal:  Biochem J       Date:  1995-08-01       Impact factor: 3.857

9.  Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.

Authors:  M Koval; R E Pagano
Journal:  J Cell Biol       Date:  1989-06       Impact factor: 10.539

10.  Sphingomyelinase treatment induces ATP-independent endocytosis.

Authors:  X Zha; L M Pierini; P L Leopold; P J Skiba; I Tabas; F R Maxfield
Journal:  J Cell Biol       Date:  1998-01-12       Impact factor: 10.539
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