An immunofluorescent study of generalized infection of human cytomegalovirus in a patient with systemic lupus erythematosus.

An autopsy case of generalized infection of cytomegalovirus (CMV) in an adult with systemic lupus erythematosus is reported. CMV infection was histologically diagnosed postmortem by the presence of the characteristic cytomegalic cells with inclusion body. In the lungs, viral antigen was seen not only in the cytomegalic cells with inclusion body but also in the cells without intranuclear inclusion body in both of the frozen and the formalin-fixed paraffin sections. Viral antigen was also detected in frozen sections of the liver. CMV was isolated from the lung and liver.