Literature DB >> 6090949

Molecular cloning of cDNA encoding human interleukin-2 receptor.

T Nikaido, A Shimizu, N Ishida, H Sabe, K Teshigawara, M Maeda, T Uchiyama, J Yodoi, T Honjo.   

Abstract

The human interleukin-2 (IL-2) receptor was purified by affinity chromatography using the anti-Tac monoclonal antibody, and its N-terminal amino acid sequence was determined. Complementary DNA clones were isolated and sequenced to reveal the primary structure of the IL-2 receptor precursor, which has 272 amino acid residues. The receptor is separated into two domains by a putative 19-residue transmembrane region. Two mRNAs (1.4 and 3.5 kilobases) hybridizing to the cDNA clone were found in human T cells bearing the IL-2 receptor. The cDNA directed synthesis of the IL-2 receptor in COS cells.

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Year:  1984        PMID： 6090949     DOI： 10.1038/311631a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  125 in total

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