Literature DB >> 6090948

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.

W J Leonard, J M Depper, G R Crabtree, S Rudikoff, J Pumphrey, R J Robb, M Krönke, P B Svetlik, N J Peffer, T A Waldmann.   

Abstract

We have purified the human T-cell growth factor (interleukin-2) receptor and have cloned, sequenced and expressed cDNAs corresponding to this receptor. We identify one gene, but two interleukin-2 receptor mRNAs which differ in their polyadenylation signals. We have isolated an additional cDNA that may correspond to an alternatively spliced mRNA that lacks a 216 base segment and appears to encode an altered membrane protein which cannot bind interleukin-2.

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Year:  1984        PMID： 6090948     DOI： 10.1038/311626a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  206 in total

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Authors:  S D Voss; T P Leary; P M Sondel; R J Robb
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-15       Impact factor: 11.205

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Journal:  Mol Cell Biol       Date:  1994-08       Impact factor: 4.272

9.  A 100-kilodalton protein is associated with the murine interleukin 2 receptor: biochemical evidence that p100 is distinct from the alpha and beta chains.

Authors:  M Sharon; J R Gnarra; W J Leonard
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

10.  Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

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Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205
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