Literature DB >> 6090396

Isolation of transformation-deficient Streptococcus pneumoniae mutants defective in control of competence, using insertion-duplication mutagenesis with the erythromycin resistance determinant of pAM beta 1.

D A Morrison, M C Trombe, M K Hayden, G A Waszak, J D Chen.   

Abstract

Several transformation-deficient mutants of Streptococcus pneumoniae were isolated after insertion-duplication mutagenesis. Mutagenesis was accomplished by transformation of competent cells with chimeric DNA formed by the ligation of TaqI fragments of pneumococcal DNA to the erythromycin resistance determinant of the streptococcal plasmid pAM beta 1. The two mutants described were characterized as defective in the control of competence induction, possibly due to a block in the production of the intercellular competence-inducing protein.

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Year:  1984        PMID： 6090396      PMCID： PMC215739          DOI： 10.1128/jb.159.3.870-876.1984

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  32 in total

1.  ON THE MECHANISM OF DEOXYRIBONUCLEATE INTEGRATION IN PNEUMOCOCCAL TRANSFORMATION.

Authors:  M S FOX; M K ALLEN
Journal:  Proc Natl Acad Sci U S A       Date:  1964-08       Impact factor: 11.205

2.  REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS.

Authors:  A TOMASZ; R D HOTCHKISS
Journal:  Proc Natl Acad Sci U S A       Date:  1964-03       Impact factor: 11.205

3.  Model for the mechanism controlling the expression of competent state in Pneumococcus cultures.

Authors:  A Tomasz
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

4.  Mutants of Diplococcus pneumoniae that lack deoxyribonucleases and other activities possibly pertinent to genetic transformation.

Authors:  S Lacks
Journal:  J Bacteriol       Date:  1970-02       Impact factor: 3.490

5.  Transformation and deoxyribonucleic acid size: extent of degradation on entry varies with size of donor.

Authors:  D A Morrison; W R Guild
Journal:  J Bacteriol       Date:  1972-12       Impact factor: 3.490

6.  On the nature of the pneumococcal activator substance.

Authors:  A Tomasz; J L Mosser
Journal:  Proc Natl Acad Sci U S A       Date:  1966-01       Impact factor: 11.205

7.  Physical and genetic hybrids formed in bacterial transformation.

Authors:  T Gurney; M S Fox
Journal:  J Mol Biol       Date:  1968-02-28       Impact factor: 5.469

8.  Purification and properties of Streptococcal competence factor isolated from chemically defined medium.

Authors:  C G Leonard; R M Cole
Journal:  J Bacteriol       Date:  1972-04       Impact factor: 3.490

9.  Control of the competent state in Pneumococcus by a hormone-like cell product: an example for a new type of regulatory mechanism in bacteria.

Authors:  A Tomasz
Journal:  Nature       Date:  1965-10-09       Impact factor: 49.962

10.  Genetic studies of recombining DNA in pneumococcal transformation.

Authors:  H Ephrussi-Taylor; T C Gray
Journal:  J Gen Physiol       Date:  1966-07       Impact factor: 4.086
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  50 in total

1.  Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae.

Authors:  F Depardieu; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2001-01       Impact factor: 5.191

2.  Competence regulation by oxygen availability and by Nox is not related to specific adjustment of central metabolism in Streptococcus pneumoniae.

Authors:  S Chapuy-Regaud; F Duthoit; L Malfroy-Mastrorillo; P Gourdon; N D Lindley; M C Trombe
Journal:  J Bacteriol       Date:  2001-05       Impact factor: 3.490

3.  Construction and analysis of a library for random insertional mutagenesis in Streptococcus pneumoniae: use for recovery of mutants defective in genetic transformation and for identification of essential genes.

Authors:  M S Lee; B A Dougherty; A C Madeo; D A Morrison
Journal:  Appl Environ Microbiol       Date:  1999-05       Impact factor: 4.792

4.  Gene expression analysis of the Streptococcus pneumoniae competence regulons by use of DNA microarrays.

Authors:  S Peterson; R T Cline; H Tettelin; V Sharov; D A Morrison
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

5.  rpoB mutation conferring rifampin resistance in Streptococcus pyogenes.

Authors:  Hélène Aubry-Damon; Marc Galimand; Guy Gerbaud; Patrice Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2002-05       Impact factor: 5.191

6.  Induction of natural competence in Streptococcus pneumoniae triggers lysis and DNA release from a subfraction of the cell population.

Authors:  Hilde Steinmoen; Eivind Knutsen; Leiv Sigve Håvarstein
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

7.  The Streptococcus pneumoniae beta-galactosidase is a surface protein.

Authors:  D Zähner; R Hakenbeck
Journal:  J Bacteriol       Date:  2000-10       Impact factor: 3.490

8.  RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae.

Authors:  Sabine Chapuy-Regaud; A David Ogunniyi; Nicole Diallo; Yvette Huet; Jean-François Desnottes; James C Paton; Sonia Escaich; Marie-Claude Trombe
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

9.  parC mutation conferring ciprofloxacin resistance in Streptococcus pyogenes BM4513.

Authors:  Rodrigo Alonso; Marc Galimand; Patrice Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

10.  Cloning and expression of the pneumococcal autolysin gene in Escherichia coli.

Authors:  E García; J L García; C Ronda; P García; R López
Journal:  Mol Gen Genet       Date:  1985
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