Literature DB >> 6090208

Synergism between phorbol ester and A23187 in superoxide production by neutrophils.

M M Dale, A Penfield.   

Abstract

Concentrations of phorbol myristate acetate and the calcium ionophore, A23187, which by themselves are minimally effective in stimulating superoxide generation in human neutrophils show marked mutual potentiation when given together. This supports the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in the stimulus/activation coupling of the respiratory burst in the neutrophil.

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Year:  1984        PMID： 6090208     DOI： 10.1016/0014-5793(84)80592-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.

Authors:  M M Dale; A Penfield
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

Review 2.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

3.  The effect of putative protein kinase C inhibitors, K252a and staurosporine, on the human neutrophil respiratory burst activated by both receptor stimulation and post-receptor mechanisms.

Authors:  B Twomey; R E Muid; M M Dale
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

4.  Phorbol ester induces rapid actin assembly in neutrophil leucocytes independently of changes in [Ca2+]i and pHi.

Authors:  P Sheterline; J E Rickard; B Boothroyd; R C Richards
Journal:  J Muscle Res Cell Motil       Date:  1986-10       Impact factor: 2.698

Review 5.  The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.

Authors:  N C Smith
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

6.  Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis.

Authors:  J R Hoult; S Nourshargh
Journal:  Br J Pharmacol       Date:  1985-11       Impact factor: 8.739

7.  Interleukin-8 primes human neutrophils for enhanced superoxide anion production.

Authors:  A Wozniak; W H Betts; G A Murphy; M Rokicinski
Journal:  Immunology       Date:  1993-08       Impact factor: 7.397

8.  The role of C-kinase in the physiological activation of the neutrophil oxidase. Evidence from using pharmacological manipulation of C-kinase activity in intact cells.

Authors:  E Cooke; M B Hallett
Journal:  Biochem J       Date:  1985-12-01       Impact factor: 3.857

Review 9.  Activation of the respiratory burst oxidase in neutrophils: on the role of membrane-derived second messengers, Ca++, and protein kinase C.

Authors:  J D Lambeth
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

10.  Synergy between phorbol esters, 1-oleyl-2-acetylglycerol, urushiol, and calcium ionophore in eliciting aggregation of marine sponge cells.

Authors:  G Weissmann; L Azaroff; S Davidson; P Dunham
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205
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