Literature DB >> 6089907

Comparison of cumene hydroperoxide- and NADPH/Fe3+/ADP-induced lipid peroxidation in heart and liver submitochondrial particles. Mechanisms of protection by succinate.

L Cavallini, M Valente, A Bindoli.   

Abstract

The NADPH/Fe3+ /ADP system stimulates lipid peroxidation both in rat liver and bovine heart submitochondrial particles, while cumene hydroperoxide is active only in rat liver submitochondrial particles. The lack of a peroxidizing effect of cumene hydroperoxide in heart submitochondrial particles was related to the absence of cytochrome P-450. When ubiquinones are extracted from rat liver and bovine heart submitochondrial particles, succinate can still partially protect the cumene hydroperoxide-induced lipid peroxidation but not the peroxidation induced by NADPH/Fe3+ /ADP. The protective effect of succinate in lipid peroxidation was referred either to the reduction of ubiquinones that can act as antioxidants in the NADPH/Fe3+ /ADP system, or to the reduction of cytochrome P-450 that acts as a peroxidase in the cumene hydroperoxide system.

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Year:  1984        PMID： 6089907     DOI： 10.1016/0005-2760(84)90174-7

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  6 in total

1.  N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro.

Authors:  Robson Luiz Puntel; Cristina Wayne Nogueira; João Batista Teixeira Rocha
Journal:  Neurochem Res       Date:  2005-03       Impact factor: 3.996

2.  tBHP induced in vitro swelling of rat liver mitochondria.

Authors:  P Kakkar; S Mehrotra; P N Viswanathan
Journal:  Mol Cell Biochem       Date:  1996-01-12       Impact factor: 3.396

3.  F1F0-ATPase, early target of the radical initiator 2,2'-azobis-(2-amidinopropane) dihydrochloride in rat liver mitochondria in vitro.

Authors:  F Beauseigneur; M Goubern; M F Chapey; J Gresti; C Vergely; M Tsoko; J Demarquoy; L Rochette; P Clouet
Journal:  Biochem J       Date:  1996-12-01       Impact factor: 3.857

4.  Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro.

Authors:  Robson L Puntel; Cristina W Nogueira; João B T Rocha
Journal:  Neurochem Res       Date:  2005-02       Impact factor: 3.996

5.  Ferrous-iron induces lipid peroxidation with little damage to energy transduction in mitochondria.

Authors:  V Shivaswamy; C K Kurup; T Ramasarma
Journal:  Mol Cell Biochem       Date:  1993-03-24       Impact factor: 3.396

6.  Effect of succinate on mitochondrial lipid peroxidation. 1. Comparative studies on ferrous ion and ADP . Fe/NADPH-induced peroxidation.

Authors:  G Szabados; A Andó; L Tretter; I Horváth
Journal:  J Bioenerg Biomembr       Date:  1987-02       Impact factor: 2.945
  6 in total

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