Literature DB >> 6089780

Evidence for intracellular formation of angiotensins: coexistence of renin and angiotensin-converting enzyme in Leydig cells of rat testis.

K N Pandey, K S Misono, T Inagami.   

Abstract

Leydig cells were purified from rat testes by discontinuous metrizamide density gradient and were shown to contain renin (EC 3.4.99.1), angiotensin-converting enzyme (dipeptidyl carboxypeptidase, (EC 3.4.15.1), and the peptide hormone angiotensins I, II and III as determined by the combined HPLC and radioimmunoassay. In germinal cells only angiotensin II (AII) was found at a significant level. These findings provide evidence for intracellular formation of AII in testicular cells and demonstrate that an intracellular renin-angiotensin system exists in normal non-transformed cells.

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Year:  1984        PMID： 6089780     DOI： 10.1016/0006-291x(84)91238-5

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Intracellular production of adrenal renin in the fetal mouse. An immuno-electron microscopical study.

Authors:  Y Kon; Y Hashimoto; H Kitagawa; M Sugimura; K Murakami
Journal:  J Anat       Date:  1991-06       Impact factor: 2.610

Review 2.  Circulating and tissue angiotensin systems.

Authors:  D J Campbell
Journal:  J Clin Invest       Date:  1987-01       Impact factor: 14.808

3.  Immunolocalization of angiotensin 1 converting enzyme in the human male genital tract by the avidin-biotin-complex method.

Authors:  F Vivet; P Callard; A Gamoudi
Journal:  Histochemistry       Date:  1987

4.  Tissue specific localization of angiotensin-(1-7) and its receptor Mas in the uterus of ovariectomized rats.

Authors:  João Vaz-Silva; Rubens L Tavares; Márcia C Ferreira; Kinulpe Honorato-Sampaio; Ines K D Cavallo; Robson A S Santos; Adelina M dos Reis; Fernando M Reis
Journal:  J Mol Histol       Date:  2012-06-09       Impact factor: 2.611

5.  Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.

Authors:  M R Ehlers; E A Fox; D J Strydom; J F Riordan
Journal:  Proc Natl Acad Sci U S A       Date:  1989-10       Impact factor: 11.205

6.  Correlative changes of plasma renin activity and serum testosterone in human internal spermatic vein after single administration of human chorionic gonadotropin.

Authors:  A Okuyama; N Kondoh; E Koh; M Takeyama; H Fujioka; M Matsuda; K Matsumoto
Journal:  Int Urol Nephrol       Date:  1989       Impact factor: 2.370

7.  Analysis by immunocytochemistry and in situ hybridization of renin and its mRNA in kidney, testis, adrenal, and pituitary of the rat.

Authors:  C F Deschepper; S H Mellon; F Cumin; J D Baxter; W F Ganong
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

Review 8.  Regulation of cardiac angiotensin-converting enzyme and angiotensin AT1 receptor gene expression in Npr1 gene-disrupted mice.

Authors:  Kailash N Pandey; Elangovan Vellaichamy
Journal:  Clin Exp Pharmacol Physiol       Date:  2009-10-16       Impact factor: 2.557

Review 9.  Hypertension, RAS, and gender: what is the role of aminopeptidases?

Authors:  María Jesús Ramírez-Expósito; José Manuel Martínez-Martos
Journal:  Heart Fail Rev       Date:  2008-01-24       Impact factor: 4.214

10.  Human ovarian theca cells are a source of renin.

Authors:  Y S Do; A Sherrod; R A Lobo; R J Paulson; T Shinagawa; S W Chen; S Kjos; W A Hsueh
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205
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