Literature DB >> 6089774

Stimulation of hepatic glycogenolysis by 12-O-tetradecanoylphorbol-13-acetate (TPA) via a calcium requiring process.

S Kimura, K Nagasaki, I Adachi, K Yamaguchi, H Fujiki, K Abe.   

Abstract

12-O-Tetradecanoylphorbol-13-acetate (TPA) stimulated glycogenolysis in perfused rat liver which was perfused with Krebs-Ringer-bicarbonate buffer containing 1 mM CaCl2 but no substrate. Verapamil (100 microM), diltiazem (100 microM) and trifluoperazin (100 microM), all inhibited the effect of TPA in the presence of CaCl2. Omission of CaCl2 from the perfusate or the addition of EGTA markedly attenuated the effect of TPA. TPA decreased net release of 45Ca from 45Ca-preloaded liver. The effect of maximal concentration of TPA (20 ng/ml) was not additive to that of 0.6 microM A23187. These data suggest that TPA increases calcium influx into hepatocytes and stimulates glycogenolysis through a calcium-calmodulin dependent mechanism.

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Year:  1984        PMID： 6089774     DOI： 10.1016/0006-291x(84)91198-7

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Calcium ions and glycogen act synergistically as inhibitors of hepatic glycogen-synthase phosphatase.

Authors:  L Mvumbi; M Bollen; W Stalmans
Journal:  Biochem J       Date:  1985-12-15       Impact factor: 3.857

2.  Inactivation of protein kinase C in rat liver during late hypoglycemic phase of sepsis.

Authors:  C Hsu; H C Jao; S L Yang; H K Hsu; M S Liu
Journal:  Mol Cell Biochem       Date:  1998-04       Impact factor: 3.396

3.  Control of glycogen phosphorylase interconversion by phorbol esters, diacylglycerols, Ca2+ and hormones in isolated rat hepatocytes.

Authors:  G van de Werve; J Proietto; B Jeanrenaud
Journal:  Biochem J       Date:  1985-11-01       Impact factor: 3.857

4.  Stimulation of hepatic glycogenolysis by phorbol 12-myristate 13-acetate.

Authors:  T B Patel
Journal:  Biochem J       Date:  1987-01-15       Impact factor: 3.857

5.  The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+.

Authors:  R V Farese; J S Davis; D E Barnes; M L Standaert; J S Babischkin; R Hock; N K Rosic; R J Pollet
Journal:  Biochem J       Date:  1985-10-15       Impact factor: 3.857

6.  Prostaglandin D2 mediates the stimulation of glycogenolysis in the liver by phorbol ester.

Authors:  E Casteleijn; J Kuiper; H C Van Rooij; J A Kamps; J F Koster; T J Van Berkel
Journal:  Biochem J       Date:  1988-02-15       Impact factor: 3.857

7.  Phorbol esters inhibit the glucocorticoid-mediated stimulation of cytosolic aspartate aminotransferase gene transcription.

Authors:  S Feilleux-Duché; M Garlatti; M Aggerbeck; J Bouguet; J Hanoune; R Barouki
Journal:  Biochem J       Date:  1994-02-01       Impact factor: 3.857

8.  Melittin stimulates liver glycogenolysis and the release of prostaglandin D2 and thromboxane B2.

Authors:  J A García-Sáinz; S M Hernández-Sotomayor; M Macías-Silva
Journal:  Biochem J       Date:  1990-07-01       Impact factor: 3.857
  8 in total

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