Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Binding of a spin-labelled chlorpromazine analogue to calmodulin.

Literature DB >> 6089743

Binding of a spin-labelled chlorpromazine analogue to calmodulin.

D Rainteau, C Wolf, G Bereziat, J Polonovski.

Abstract

The binding of a spin-labelled derivative of chlorpromazine to calmodulin was investigated by e.s.r. spectrometry. The completion of the spectroscopic changes requires the presence of 4 Ca2+ ions per calmodulin molecule. The influences of various physicochemical factors (pH, ionic strength) are discussed in relation to the nature (hydrophobic and polar) of the interactions that hold the drug-calmodulin complex together.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1984 PMID： 6089743 PMCID： PMC1144095 DOI： 10.1042/bj2210659

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

17 in total

1. Phenothiazine antagonism of calmodulin: a structurally-nonspecific interaction.

Authors: B D Roufogalis
Journal: Biochem Biophys Res Commun Date: 1981-02-12 Impact factor: 3.575

2. Spin labeled calmodulin: a new probe for studying Ca2+ and macromolecular interactions.

Authors: P B Hewgley; D Puett
Journal: Ann N Y Acad Sci Date: 1980 Impact factor: 5.691

3. A thermodynamic and electron paramagnetic resonance study of structural changes in calmodulin induced by aluminum binding.

Authors: N Siegel; R Coughlin; A Haug
Journal: Biochem Biophys Res Commun Date: 1983-09-15 Impact factor: 3.575

Review 4. Calmodulin.

Authors: C B Klee; T C Vanaman
Journal: Adv Protein Chem Date: 1982

5. Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.

Authors: A R Means
Journal: Recent Prog Horm Res Date: 1981

6. Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes.

Authors: J Haiech; C B Klee; J G Demaille
Journal: Biochemistry Date: 1981-06-23 Impact factor: 3.162

7. Calcium-induced exposure of a hydrophobic surface on calmodulin.

Authors: D C LaPorte; B M Wierman; D R Storm
Journal: Biochemistry Date: 1980-08-05 Impact factor: 3.162

8. Hydrophobic interaction of the Ca2+-calmodulin complex with calmodulin antagonists. Naphthalenesulfonamide derivatives.

Authors: T Tanaka; T Ohmura; H Hidaka
Journal: Mol Pharmacol Date: 1982-09 Impact factor: 4.436

Binding of a spin-labelled chlorpromazine analogue to calmodulin.

1. Phenothiazine antagonism of calmodulin: a structurally-nonspecific interaction.

2. Spin labeled calmodulin: a new probe for studying Ca2+ and macromolecular interactions.

3. A thermodynamic and electron paramagnetic resonance study of structural changes in calmodulin induced by aluminum binding.

Review 4. Calmodulin.

5. Calmodulin: properties, intracellular localization, and multiple roles in cell regulation.

6. Effects of cations on affinity of calmodulin for calcium: ordered binding of calcium ions allows the specific activation of calmodulin-stimulated enzymes.

7. Calcium-induced exposure of a hydrophobic surface on calmodulin.

8. Hydrophobic interaction of the Ca2+-calmodulin complex with calmodulin antagonists. Naphthalenesulfonamide derivatives.

9. Localization of a trifluoperazine binding site on troponin C.

Review 10. Pharmacological antagonism of calmodulin.

1. Interaction between calmodulin and five different spin-labelled chlorophenothiazines.

2. Chlorpromazine inhibits nitric oxide-mediated increase in intracellular cGMP in a mouse teratocarcinoma cell line.

3. Trifluoperazine increases fatty acid turnover in phospholipids in cultured human fibroblasts.

4. Chlorpromazine inhibits tumour necrosis factor synthesis and cytotoxicity in vitro.