Literature DB >> 6089526

Quantitation of arthritis by 99mTc-uptake measurements in the mouse knee-joint: correlation with histological joint inflammation scores.

J W Lens, W B van den Berg, L B van de Putte.   

Abstract

A method is described to detect and to quantitate inflammation in knee-joints of mice. Approximately 10 muCi 99mTechnetium pertechnetate (99mTc) is injected subcutaneously in the neck region and the accumulation of the short-lived isotope in the knee-joint is detected by external gamma counting. 99mTc-uptake values correlate well with histological grading of joint inflammation at various intervals after induction of the inflammation. The method can be used to detect changes in activity of unilateral as well as bilateral joint inflammation using either the ratio of 99mTc uptake in the right knee versus that in the left knee or absolute 99mTc-uptake values.

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Year:  1984        PMID： 6089526     DOI： 10.1007/bf01978915

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

Review 1.  The use of radioisotopes in normal and diseased joints.

Authors:  W C Dick
Journal:  Semin Arthritis Rheum       Date:  1972       Impact factor: 5.532

2.  The pertechnetate joint scan. II. Clinical correlations.

Authors:  F A Green; M T Hays
Journal:  Ann Rheum Dis       Date:  1972-07       Impact factor: 19.103

3.  The pertechnetate joint scan. I. Timing.

Authors:  M T Hays; F A Green
Journal:  Ann Rheum Dis       Date:  1972-07       Impact factor: 19.103

4.  Tc-99m in the study of systemic inflammatory activity in rheumatoid arthritis. A preliminary report.

Authors:  M Oka; A Rekonen; A Ruotsi
Journal:  Acta Rheumatol Scand       Date:  1971

5.  Joint scanning in rheumatoid arthritis: a literature review.

Authors:  D J Wallace; M Brachman; J R Klinenberg
Journal:  Semin Arthritis Rheum       Date:  1981-08       Impact factor: 5.532

6.  Rapid assessment of 99mTc-pertechnetate uptake in the knee joint as a parameter of inflammatory activity.

Authors:  A M Boerbooms; W C Buys
Journal:  Arthritis Rheum       Date:  1978-04

7.  Detection and quantification of experimental joint inflammation in mice by measurement of 99mTc-pertechnetate uptake.

Authors:  M W Kruijsen; W B van den Berg; L B van de Putte; W J van den Broek
Journal:  Agents Actions       Date:  1981-12

8.  99mTc-pertechnetate uptake measurement in the rabbit knee-joint. II. Kinetics of 99mTcO-4 in normal and arthritic rabbit knee-joints.

Authors:  H J van Beusekom; L B van de Putte; W C Buijs; W J van den Broek; W B van den Berg
Journal:  Scand J Rheumatol       Date:  1983       Impact factor: 3.641

9.  Assessment and interpretation of radiopharmaceutical joint imaging in an animal model of arthritis.

Authors:  K L Rosenspire; M Blau; A C Kennedy; F A Green
Journal:  Arthritis Rheum       Date:  1981-05

10.  99mTc-pertechnetate uptake measurement in the rabbit knee-joint.

Authors:  H J van Beusekom; W J van den Broek; L B van de Putte; W C Buys; W B van den Berg
Journal:  J Rheumatol       Date:  1981 Jan-Feb       Impact factor: 4.666
  10 in total
  24 in total

1.  Direct effect of murine rIL-1 on cartilage metabolism in vivo.

Authors:  A A van de Loo; H M van Beuningen; P L van Lent; W B van den Berg
Journal:  Agents Actions       Date:  1989-01

2.  Effect of interleukin 17 on proteoglycan degradation in murine knee joints.

Authors:  J Dudler; N Renggli-Zulliger; N Busso; M Lotz; A So
Journal:  Ann Rheum Dis       Date:  2000-07       Impact factor: 19.103

3.  Monoclonal anti-Ia antibodies suppress the flare up reaction of antigen induced arthritis in mice.

Authors:  M F van den Broek; W B van den Berg; L B van de Putte
Journal:  Clin Exp Immunol       Date:  1986-11       Impact factor: 4.330

4.  Pharmacological studies of antigen-induced arthritis in BALB/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents.

Authors:  I M Hunneyball; M J Crossley; M Spowage
Journal:  Agents Actions       Date:  1986-06

5.  Experimental allergic arthritis in mice: effects of local enzyme therapy with native and cationic derivatives.

Authors:  W B van den Berg; J Schalkwijk; L A Joosten; L B van de Putte
Journal:  Agents Actions       Date:  1986-01

6.  Treatment of pigmented villonodular synovitis of the knee with yttrium-90 silicate: prospective evaluations by arthroscopy, histology, and 99mTc pertechnetate uptake measurements.

Authors:  M J Franssen; A M Boerbooms; R P Karthaus; W C Buijs; L B van de Putte
Journal:  Ann Rheum Dis       Date:  1989-12       Impact factor: 19.103

7.  Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction.

Authors:  Leo A B Joosten; Ruben L Smeets; Marije I Koenders; Liduine A M van den Bersselaar; Monique M A Helsen; Birgitte Oppers-Walgreen; Erik Lubberts; Yoichiro Iwakura; Fons A J van de Loo; Wim B van den Berg
Journal:  Am J Pathol       Date:  2004-09       Impact factor: 4.307

8.  Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice.

Authors:  J Schalkwijk; W B van den Berg; L B van de Putte; L A Joosten; L van den Bersselaar
Journal:  J Clin Invest       Date:  1985-07       Impact factor: 14.808

9.  In vivo role of phagocytic synovial lining cells in onset of experimental arthritis.

Authors:  P L Van Lent; A E Van den Hoek; L A Van den Bersselaar; M F Spanjaards; N Van Rooijen; C D Dijkstra; L B Van de Putte; W B Van den Berg
Journal:  Am J Pathol       Date:  1993-10       Impact factor: 4.307

10.  Effects of murine recombinant interleukin 1 on synovial joints in mice: measurement of patellar cartilage metabolism and joint inflammation.

Authors:  A A van de Loo; W B van den Berg
Journal:  Ann Rheum Dis       Date:  1990-04       Impact factor: 19.103
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