Literature DB >> 6089350

Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.

T H Lee, J E Coligan, J G Sodroski, W A Haseltine, S Z Salahuddin, F Wong-Staal, R C Gallo, M Essex.   

Abstract

Antibodies in sera from patients with adult T-cell leukemia-lymphoma or from healthy carriers of type I human T-cell leukemia virus (HTLV) recognize an antigen of approximately 42 kilodaltons (p42) in cell lines infected with HTLV-I. Radiolabel sequence analysis of cyanogen bromide fragments of p42 led to the conclusion that this antigen is encoded in part by LOR, a conserved portion of the "X" region that is flanked by the envelope gene and the 3' long terminal repeat of HTLV-I. It is possible that this novel product mediates the unique transformation properties of the HTLV family.

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Year:  1984        PMID： 6089350     DOI： 10.1126/science.6089350

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  64 in total

1.  Subnuclear localization of the trans-activating protein of human T-cell leukemia virus type I.

Authors:  D J Slamon; W J Boyle; D E Keith; M F Press; D W Golde; L M Souza
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

2.  Localization of sequences responsible for trans-activation of the equine infectious anemia virus long terminal repeat.

Authors:  L Sherman; A Gazit; A Yaniv; T Kawakami; J E Dahlberg; S R Tronick
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

3.  Mutational analysis of human T-cell leukemia virus type 2 Tax.

Authors:  T M Ross; A C Minella; Z Y Fang; S M Pettiford; P L Green
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

Review 4.  The epidemiology of HTLV-I infection.

Authors:  N Mueller
Journal:  Cancer Causes Control       Date:  1991-01       Impact factor: 2.506

5.  Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I.

Authors:  A De Rossi; G Franchini; A Aldovini; A Del Mistro; L Chieco-Bianchi; R C Gallo; F Wong-Staal
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

6.  A human CD4+ T-cell line expresses functional CD64 (Fc gamma RI), CD32 (Fc gamma RII), and CD16 (Fc gamma RIII) receptors but these do not enhance the infectivity of HIV-1-IgG complexes.

Authors:  L McLain; N J Dimmock
Journal:  Immunology       Date:  1997-01       Impact factor: 7.397

7.  Indirect binding of human T-cell leukemia virus type I tax1 to a responsive element in the viral long terminal repeat.

Authors:  S J Marriott; I Boros; J F Duvall; J N Brady
Journal:  Mol Cell Biol       Date:  1989-10       Impact factor: 4.272

8.  Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

Authors:  T Nosaka; H Siomi; Y Adachi; M Ishibashi; S Kubota; M Maki; M Hatanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

9.  Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.

Authors:  K Shimotohno; Y Takahashi; N Shimizu; T Gojobori; D W Golde; I S Chen; M Miwa; T Sugimura
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

10.  Characterization of cellular factors that interact with the human T-cell leukemia virus type I p40x-responsive 21-base-pair sequence.

Authors:  K T Jeang; I Boros; J Brady; M Radonovich; G Khoury
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103
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