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Literature DB >> 6089338

Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin.

Abstract

Four surface antigens previously recognized only in macrophages are present on human small cell lung carcinoma cells and tumors. Cancerous cells may arise from macrophage precursors in bone marrow, and these precursors migrate to lung to participate in the repair of damaged tissue produced by continuous heavy smoking. The characteristic presence of neuropeptides such as bombesin in small cell carcinoma, when considered along with these findings, presents new possibilities for the role of such peptides in nervous, endocrine, and immune system function.

Entities: Disease Gene Species

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Year: 1984 PMID： 6089338 DOI： 10.1126/science.6089338

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

21 in total

1. Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.

Authors: C B Pert; J M Hill; M R Ruff; R M Berman; W G Robey; L O Arthur; F W Ruscetti; W L Farrar
Journal: Proc Natl Acad Sci U S A Date: 1986-12 Impact factor: 11.205

Review 2. On the origin of cancer metastasis.

Authors: Thomas N Seyfried; Leanne C Huysentruyt
Journal: Crit Rev Oncog Date: 2013

Review 3. Differential gene expression in autoimmune mice.

Authors: J D Mountz; J F Mushinski; A D Steinberg
Journal: Surv Immunol Res Date: 1985

4. Differential expression of intermediate filament proteins distinguishes classic from variant small-cell lung cancer cell lines.

Authors: J L Broers; D N Carney; L de Ley; G P Vooijs; F C Ramaekers
Journal: Proc Natl Acad Sci U S A Date: 1985-07 Impact factor: 11.205

5. Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines.

Authors: M R Ruff; W L Farrar; C B Pert
Journal: Proc Natl Acad Sci U S A Date: 1986-09 Impact factor: 11.205

Small cell carcinoma of the lung: macrophage-specific antigens suggest hemopoietic stem cell origin.

1. Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.

Review 2. On the origin of cancer metastasis.

Review 3. Differential gene expression in autoimmune mice.

4. Differential expression of intermediate filament proteins distinguishes classic from variant small-cell lung cancer cell lines.

5. Interferon gamma and granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small-cell lung cancer cell lines.

6. Melanoma x macrophage hybrids with enhanced metastatic potential.

7. PADI4 and tumourigenesis.

8. Cancer as a metabolic disease.

Review 9. Perspectives on the mesenchymal origin of metastatic cancer.

Review 10. The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma.