Literature DB >> 6089137

Chronic atropine treatment causes increase in VIP receptors in rat cerebral cortex.

J Abens, A Westlind, T Bartfai.   

Abstract

Chronic atropine treatment (14 days, 20 mg X day-1 X kg-1 SC) caused a 75% increase in the number of VIP receptors in the rat cerebral cortex. The affinity of these receptors for 125I-VIP was not altered significantly by the atropine treatment. The same treatment led to a 20% decrease in VIP tissue levels. Muscarinic receptor number was also increased by 26%. The results indicate that interactions between VIP- and muscarinic receptors may be of importance in the rat cerebral cortex.

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Year:  1984        PMID： 6089137     DOI： 10.1016/0196-9781(84)90237-7

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  2 in total

1.  Effect of acute and chronic diisopropylfluorophosphate and atropine administration on somatostatin binding in the rat frontoparietal cortex and hippocampus.

Authors:  I A Alonso; J C Prieto; E Arilla
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

2.  Effects of atropine treatment on in vitro and in vivo binding of 4-[125I]-dexetimide to central and myocardial muscarinic receptors.

Authors:  Y Uno; K Matsumura; U Scheffel; A A Wilson; R F Dannals; H N Wagner
Journal:  Eur J Nucl Med       Date:  1991
  2 in total

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