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Literature DB >> 6089100

cGMP and cAMP inhibit tension development in skinned coronary arteries.

G Pfitzer, F Hofmann, J DiSalvo, J C Rüegg.

Abstract

The effects of physiological concentrations of cGMP and cAMP on tension development in skinned coronary arteries (Triton X-100) were studied. cGMP inhibited tension elicited at intermediate Ca2+ concentrations at pH 7.0 but not at more acidic or alkaline pH values. cAMP, on the other hand, decreased submaximal tension development independent of pH (from pH 6.5 to pH 7.2). Neither nucleotide affected tension development at maximally activating Ca2+ concentrations.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6089100 DOI： 10.1007/bf00582596

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

28 in total

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10. Vascular smooth muscle. Calmodulin and cyclic AMP-dependent protein kinase after calcium sensitivity in porcine carotid skinned fibers.

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24 in total

1. Endothelium-dependent calcium-induced relaxation in the presence of Ca2+-antagonists in canine depolarized coronary arteries.

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Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

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Authors: J C Rüegg; G Pfitzer
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4. Cyclic GMP-dependent protein kinase relaxes skinned fibers from guinea pig taenia coli but not from chicken gizzard.

Authors: G Pfitzer; L Merkel; J C Rüegg; F Hofmann
Journal: Pflugers Arch Date: 1986-07 Impact factor: 3.657

5. Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle.

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Journal: Naturwissenschaften Date: 1989-12

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Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

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9. Forskolin Changes the Relationship between Cytosolic Ca and Contraction in Guinea Pig Ileum.

Authors: Koon Hee Han; Gap Jin Cheon; Dong Soo Yeon; Seong Chun Kwon
Journal: Korean J Physiol Pharmacol Date: 2009-06-30 Impact factor: 2.016

10. The relationship of KCl- and prostaglandin F2 alpha-mediated increases in tension of the porcine coronary artery with changes in intracellular Ca2+ measured with fura-2.

Authors: J L Balwierczak
Journal: Br J Pharmacol Date: 1991-10 Impact factor: 8.739