Literature DB >> 6088992

Sequence requirements for nuclear location of simian virus 40 large-T antigen.

D Kalderon, W D Richardson, A F Markham, A E Smith.   

Abstract

A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear location.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6088992     DOI： 10.1038/311033a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  424 in total

1.  Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations.

Authors:  B H Spain; C J Larson; L S Shihabuddin; F H Gage; I M Verma
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

2.  A beta-stranded motif drives capsid protein oligomers of the parvovirus minute virus of mice into the nucleus for viral assembly.

Authors:  E Lombardo; J C Ramírez; M Agbandje-McKenna; J M Almendral
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

3.  Kinetics of protein import into isolated Xenopus oocyte nuclei.

Authors:  T Radtke; D Schmalz; E Coutavas; T M Soliman; R Peters
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-20       Impact factor: 11.205

4.  Nuclear activities of basic fibroblast growth factor: potentiation of low-serum growth mediated by natural or chimeric nuclear localization signals.

Authors:  M Arese; Y Chen; R Z Florkiewicz; A Gualandris; B Shen; D B Rifkin
Journal:  Mol Biol Cell       Date:  1999-05       Impact factor: 4.138

5.  Unique motif for nucleolar retention and nuclear export regulated by phosphorylation.

Authors:  Frédéric Catez; Monique Erard; Nathalie Schaerer-Uthurralt; Karine Kindbeiter; Jean-Jacques Madjar; Jean-Jacques Diaz
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

6.  Integrase mediates nuclear localization of Ty3.

Authors:  S S Lin; M H Nymark-McMahon; L Yieh; S B Sandmeyer
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

7.  Peptides containing cyclin/Cdk-nuclear localization signal motifs derived from viral initiator proteins bind to DNA when unphosphorylated.

Authors:  Ronald J Kim; Stephanie Moine; Danielle K Reese; Peter A Bullock
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

8.  The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule.

Authors:  M A Hardwicke; P J Vaughan; R E Sekulovich; R O'Conner; R M Sandri-Goldin
Journal:  J Virol       Date:  1989-11       Impact factor: 5.103

9.  The RelA nuclear localization signal folds upon binding to IκBα.

Authors:  Carla F Cervantes; Simon Bergqvist; Magnus Kjaergaard; Gerard Kroon; Shih-Che Sue; H Jane Dyson; Elizabeth A Komives
Journal:  J Mol Biol       Date:  2010-11-19       Impact factor: 5.469

10.  Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication.

Authors:  I J Mohr; M P Fairman; B Stillman; Y Gluzman
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.