Leukotriene involvement in pathologic processes.

Leukotrienes (LTs) have potent biologic properties, suggesting a role in human disease. LTB4 release has been detected in inflammatory exudates in the rat. LTC4 release has been detected after antigen challenge of lung tissue in vitro and in tear fluid in man in vivo. There is some evidence to suggest that LTB4 is a mediator of ulcerative colitis in man and considerable evidence to suggest that LTB4, LTC4, and LTD4 may be involved in the pathogenesis of psoriasis.