Literature DB >> 6088293

Modulation of junctional permeability.

W C De Mello.   

Abstract

Changes in intercellular coupling can be accomplished by continuous synthesis and destruction of intercellular channels and through a modulation of unit channel permeability. The increase in free [Ca2+]i caused by activation of sodium-calcium exchange or by metabolic inhibition leads to cell decoupling. In embryonic cells the conductance of the gap junction is strongly dependent on pHi. The exact role of Ca2+ and H+ in the physiological modulation of junctional conductance remains unknown. The cyclic AMP (cAMP)-calcium hypothesis is presented. According to this view, cAMP modulates the junctional permeability through specific kinases. A feedback mechanism between calcium and cAMP might be relevant in the physiological control of junctional conductance.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6088293

Source DB:  PubMed          Journal:  Fed Proc        ISSN： 0014-9446


  8 in total

1.  Structural changes in cardiac gap junctions after hypoxia and reoxygenation: a quantitative freeze-fracture analysis.

Authors:  A M De Mazière; D W Scheuermann
Journal:  Cell Tissue Res       Date:  1990-07       Impact factor: 5.249

Review 2.  Drug effects on the electrocardiogram. A review of their clinical importance.

Authors:  J D Symanski; L S Gettes
Journal:  Drugs       Date:  1993-08       Impact factor: 9.546

3.  Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells.

Authors:  C C Chang; J E Trosko; H J Kung; D Bombick; F Matsumura
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

4.  Calcium exchange in the resting and electrically stimulated canine myocardium.

Authors:  N J Lodge; A L Bassett; H Gelband
Journal:  Pflugers Arch       Date:  1985-09       Impact factor: 3.657

5.  Factors determining spontaneous ventricular defibrillation.

Authors:  N Tribulova; M Manoach
Journal:  Exp Clin Cardiol       Date:  2001

6.  Transformed human bronchial epithelial cells (BEAS-2B) alter the growth and morphology of normal human bronchial epithelial cells in vitro.

Authors:  C D Albright; R T Jones; E A Hudson; J A Fontana; B F Trump; J H Resau
Journal:  Cell Biol Toxicol       Date:  1990-10       Impact factor: 6.691

7.  The effect of high K+ depolarization and verapamil on 45Ca2+ fluxes in the canine myocardium.

Authors:  N J Lodge; A L Bassett; H Gelband
Journal:  Pflugers Arch       Date:  1985-02       Impact factor: 3.657

8.  Adenovirus-dependent changes in cell membrane permeability: role of Na+, K+-ATPase.

Authors:  P Seth; I Pastan; M C Willingham
Journal:  J Virol       Date:  1987-03       Impact factor: 5.103
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.