Literature DB >> 6088277

The partitioning of delta 1-tetrahydrocannabinol into erythrocyte membranes in vivo and its effect on membrane fluidity.

J T Leuschner, D R Wing, D J Harvey, G A Brent, C E Dempsey, A Watts, W D Paton.   

Abstract

delta 1-Tetrahydrocannabinol (delta 1-THC) has been quantified directly in erythrocyte membranes from drug-treated mice using gas chromatography/mass spectrometry. Concentrations of approximately 6 ng delta 1-THC/mg membrane protein (10(-5) M) were found when effects of the drug on behavior were prevalent. At these concentrations the drug produced a decrease in membrane order as measured by ESR.

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Year:  1984        PMID： 6088277     DOI： 10.1007/bf01951999

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  25 in total

1.  A FAST, SIMPLE AND RELIABLE METHOD FOR THE MICRODETERMINATION OF PHOSPHORUS IN BIOLOGICAL MATERIALS.

Authors:  W R MORRISON
Journal:  Anal Biochem       Date:  1964-02       Impact factor: 3.365

2.  Rhodopsin-lipid associations in bovine rod outer segment membranes. Identification of immobilized lipid by spin-labels.

Authors:  A Watts; I D Volotovski; D Marsh
Journal:  Biochemistry       Date:  1979-10-30       Impact factor: 3.162

3.  Blood and brain levels of delta1-tetrahydrocannabinol in mice--the effect of 7-hydroxy-delta1-tetrahydrocannabinol.

Authors:  E W Gill; D K Lawrence
Journal:  Biochem Pharmacol       Date:  1974-03-15       Impact factor: 5.858

4.  Brain levels of 1 -tetrahydrocannabinol and its metabolites in mice--correlation with behaviour, and the effect of the metabolic inhibitors SKF 525A and piperonyl butoxide.

Authors:  E W Gill; G Jones
Journal:  Biochem Pharmacol       Date:  1972-08-15       Impact factor: 5.858

5.  The membrane binding of morphine, diphenylhydantoin, and tetrahydrocannabinol.

Authors:  P Seeman; M Chau-Wong; S Moyyen
Journal:  Can J Physiol Pharmacol       Date:  1972-12       Impact factor: 2.273

6.  Binding of delta-1-tetrahydrocannabinol to human plasma proteins.

Authors:  M Wahlqvist; I M Nilsson; F Sandberg; S Agurell
Journal:  Biochem Pharmacol       Date:  1970-09       Impact factor: 5.858

7.  Plasma and brain levels of delta 6-THC and seven monooxygenated metabolites correlated to the cataleptic effect in the mouse.

Authors:  A Ohlsson; M Widman; S Carlsson; T Ryman; C Strid
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1980-10

8.  Brain spectrin, a membrane-associated protein related in structure and function to erythrocyte spectrin.

Authors:  V Bennett; J Davis; W E Fowler
Journal:  Nature       Date:  1982-09-09       Impact factor: 49.962

9.  The perturbation of lipid bilayers by general anesthetics: a quantitative test of the disordered lipid hypothesis.

Authors:  K Y Pang; L M Braswell; L Chang; T J Sommer; K W Miller
Journal:  Mol Pharmacol       Date:  1980-07       Impact factor: 4.436

10.  Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues.

Authors:  V Bennett
Journal:  Nature       Date:  1979-10-18       Impact factor: 49.962
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  5 in total

1.  Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes.

Authors:  A S Bloom; W S Edgemond; J C Moldvan
Journal:  Neurochem Res       Date:  1997-05       Impact factor: 3.996

Review 2.  Preclinical studies on the reinforcing effects of cannabinoids. A tribute to the scientific research of Dr. Steve Goldberg.

Authors:  Gianluigi Tanda
Journal:  Psychopharmacology (Berl)       Date:  2016-03-30       Impact factor: 4.530

3.  Metabolism of n-hexyl-homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse.

Authors:  N K Brown; D J Harvey
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1988 Jul-Sep       Impact factor: 2.441

Review 4.  Cannabinoids: reward, dependence, and underlying neurochemical mechanisms--a review of recent preclinical data.

Authors:  Gianluigi Tanda; Steven R Goldberg
Journal:  Psychopharmacology (Berl)       Date:  2003-06-24       Impact factor: 4.530

Review 5.  Brain activity of anandamide: a rewarding bliss?

Authors:  Maria Scherma; Paolo Masia; Valentina Satta; Walter Fratta; Paola Fadda; Gianluigi Tanda
Journal:  Acta Pharmacol Sin       Date:  2018-07-26       Impact factor: 6.150
  5 in total

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