Literature DB >> 6088104

Activated oxygen and mammalian nitrate biosynthesis.

B J Dull, J H Hotchkiss.   

Abstract

The oxidation of NH3 to NO3- by rat liver in vitro is described. A xanthine-xanthine oxidase reaction also oxidized NH3 to NO3- when H2O2 was added. An in vivo inhibitor of superoxide dismutase enhanced the in vitro liver conversion of NH3 to NO3-. Thus, intracellular oxidation by activated oxygen likely represents the source of endogenously formed NO3- in mammals.

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Year:  1984        PMID： 6088104     DOI： 10.1093/carcin/5.9.1161

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  4 in total

1.  The role of nitrate, nitrite and N-nitrosamines in carcinogenesis of colon tumours following ureterosigmoidostomy.

Authors:  T Kälble; A R Tricker; K Möhring; M R Berger; H Geiss; G Staehler
Journal:  Urol Res       Date:  1990

2.  Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

Authors:  D J Stuehr; M A Marletta
Journal:  Proc Natl Acad Sci U S A       Date:  1985-11       Impact factor: 11.205

3.  Specific amino acid (L-arginine) requirement for the microbiostatic activity of murine macrophages.

Authors:  D L Granger; J B Hibbs; J R Perfect; D T Durack
Journal:  J Clin Invest       Date:  1988-04       Impact factor: 14.808

4.  Nitrate biosynthesis in the rat. Precursor-product relationships with respect to ammonia.

Authors:  D A Wagner; L L Moldawer; J J Pomposelli; S R Tannenbaum; V R Young
Journal:  Biochem J       Date:  1985-12-01       Impact factor: 3.857
  4 in total

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