Literature DB >> 6087812

Superoxide release by neutrophils: synergistic effects of a phorbol ester and a calcium ionophore.

J M Robinson, J A Badwey, M L Karnovsky, M J Karnovsky.   

Abstract

Exposure to combined suboptimal concentrations of 4 beta-phorbol 12-myristate 13-acetate and the calcium ionophore A23187 stimulates superoxide release from guinea pig neutrophils to rates ca. 3.5-fold greater than the sum of the rates elicited by each of the agents added separately. This effect was largely dependent upon the presence of calcium in the extracellular medium. The data are discussed in relation to recent reports concerning the interactions of phorbol-esters with cells and the mechanism of activation of superoxide release by neutrophils.

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Year:  1984        PMID： 6087812     DOI： 10.1016/s0006-291x(84)80095-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

1.  Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.

Authors:  M M Dale; A Penfield
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

2.  Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester.

Authors:  A Poulos; B S Robinson; A Ferrante; D P Harvey; S J Hardy; A W Murray
Journal:  Immunology       Date:  1991-05       Impact factor: 7.397

Review 3.  Reactive oxygen species in phagocytic leukocytes.

Authors:  John M Robinson
Journal:  Histochem Cell Biol       Date:  2008-07-03       Impact factor: 4.304

Review 4.  Protein phosphorylation associated with the stimulation of neutrophils. Modulation of superoxide production by protein kinase C and calcium.

Authors:  P G Heyworth; J A Badwey
Journal:  J Bioenerg Biomembr       Date:  1990-02       Impact factor: 2.945

Review 5.  The role of phosphoinositides in signal transduction.

Authors:  M C Sekar; L E Hokin
Journal:  J Membr Biol       Date:  1986       Impact factor: 1.843

Review 6.  Activation of the neutrophil respiratory burst by chemoattractants: regulation of the N-formyl peptide receptor in the plasma membrane.

Authors:  A J Jesaitis; R A Allen
Journal:  J Bioenerg Biomembr       Date:  1988-12       Impact factor: 2.945

7.  Dietary cholesterol-induced changes in macrophage characteristics. Relationship to atherosclerosis.

Authors:  K A Rogers; R L Hoover; J J Castellot; J M Robinson; M J Karnovsky
Journal:  Am J Pathol       Date:  1986-11       Impact factor: 4.307

Review 8.  The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.

Authors:  N C Smith
Journal:  Parasitol Res       Date:  1989       Impact factor: 2.289

9.  A role for protein kinase C in the production of free oxygen radicals in response to Nippostrongylus brasiliensis.

Authors:  N C Smith
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

10.  Endothelial superoxide production in the isolated rat heart during early reperfusion after ischemia. A histochemical study.

Authors:  C F Babbs; M D Cregor; J J Turek; S F Badylak
Journal:  Am J Pathol       Date:  1991-11       Impact factor: 4.307
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