Literature DB >> 6086827

A leader sequence is present on mRNA A of avian infectious bronchitis virus.

T D Brown, M E Boursnell, M M Binns.   

Abstract

The subgenomic mRNAs of the fowl coronavirus infectious bronchitis virus (IBV) form a 3' co-terminal or 'nested' set. The RNase T1 oligonucleotide mapping data which demonstrated this form of sequence organization provided no evidence for the presence of non-contiguous (leader) sequences fused to the 5' termini of the mRNAs. However, we have been able to demonstrate, by extension of an end-labelled synthetic oligonucleotide primer, the presence of a leader sequence on IBV mRNA A. Sequencing by the chemical degradation method of the extended product has yielded the almost complete sequence of the 60 base leader and its point of fusion to the sequence of the virus genomic RNA.

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Year:  1984        PMID： 6086827     DOI： 10.1099/0022-1317-65-8-1437

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  18 in total

1.  Minus-strand copies of replicating coronavirus mRNAs contain antileaders.

Authors:  P B Sethna; M A Hofmann; D A Brian
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

2.  Coronavirus subgenomic minus-strand RNAs and the potential for mRNA replicons.

Authors:  P B Sethna; S L Hung; D A Brian
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

3.  The use of a random priming procedure to generate cDNA libraries of infectious bronchitis virus, a large RNA virus.

Authors:  M M Binns; M E Boursnell; I J Foulds; T D Brown
Journal:  J Virol Methods       Date:  1985-07       Impact factor: 2.014

4.  Characterization and translation of transmissible gastroenteritis virus mRNAs.

Authors:  L Jacobs; B A van der Zeijst; M C Horzinek
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103

5.  A new typing method for the avian infectious bronchitis virus using polymerase chain reaction and restriction enzyme fragment length polymorphism.

Authors:  Z Lin; A Kato; Y Kudou; S Ueda
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

6.  A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.

Authors:  M A Hofmann; S D Senanayake; D A Brian
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-15       Impact factor: 11.205

7.  The nucleotide sequence of the extreme 5' end of the avian coronavirus genome; implications for the discontinuous mRNA synthesis.

Authors:  P J Bredenbeek; J F Noten; J A Lenstra; M C Horzinek; B A van der Zeijst; W J Spaan
Journal:  Nucleic Acids Res       Date:  1986-10-10       Impact factor: 16.971

8.  Differential premature termination of transcription as a proposed mechanism for the regulation of coronavirus gene expression.

Authors:  D A Konings; P J Bredenbeek; J F Noten; P Hogeweg; W J Spaan
Journal:  Nucleic Acids Res       Date:  1988-11-25       Impact factor: 16.971

9.  An efficient ribosomal frame-shifting signal in the polymerase-encoding region of the coronavirus IBV.

Authors:  I Brierley; M E Boursnell; M M Binns; B Bilimoria; V C Blok; T D Brown; S C Inglis
Journal:  EMBO J       Date:  1987-12-01       Impact factor: 11.598

10.  Sequence analysis of the leader RNA of two porcine coronaviruses: transmissible gastroenteritis virus and porcine respiratory coronavirus.

Authors:  K W Page; P Britton; M E Boursnell
Journal:  Virus Genes       Date:  1990-12       Impact factor: 2.332
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