Literature DB >> 6085825

Oncodevelopmental and hormonal regulation of alpha 1-fetoprotein gene expression.

L Belanger, P Baril, M Guertin, M C Gingras, H Gourdeau, A Anderson, D Hamel, J M Boucher.   

Abstract

The main features of the oncodevelopmental biology of alpha 1-fetoprotein (AFP) are reviewed. Progress made in the molecular biology of AFP gene regulation is discussed and we present our recent data on the mechanisms of AFP suppression by glucocorticoid hormones. The relationship between AFP gene transcription and cell replication is examined, and it is suggested that the degree of methylation of the AFP gene (or of co-methylated regulatory DNA sequences) conditions its response to hormones.

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Year:  1983        PMID： 6085825     DOI： 10.1016/0065-2571(83)90009-2

Source DB:  PubMed          Journal:  Adv Enzyme Regul        ISSN： 0065-2571


  12 in total

Review 1.  Role of different epithelial cell types in liver ontogenesis, regeneration and neoplasia.

Authors:  N Marceau; M J Blouin; L Germain; M Noel
Journal:  In Vitro Cell Dev Biol       Date:  1989-04

2.  Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression.

Authors:  L Khamzina; P Borgeat
Journal:  Mol Biol Cell       Date:  1998-05       Impact factor: 4.138

3.  Attachment and multiplication, morphology and protein production of human fetal primary liver cells cultured in hormonally defined media.

Authors:  M Salas-Prato; J F Tanguay; Y Lefebvre; D Wojciechowicz; H H Liem; D W Barnes; G Ouellette; U Muller-Eberhard
Journal:  In Vitro Cell Dev Biol       Date:  1988-03

4.  Modulation of the liver specific phenotype in the human hepatoblastoma line Hep G2.

Authors:  J H Kelly; G J Darlington
Journal:  In Vitro Cell Dev Biol       Date:  1989-02

5.  Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes.

Authors:  K Sawadaishi; T Morinaga; T Tamaoki
Journal:  Mol Cell Biol       Date:  1988-12       Impact factor: 4.272

6.  Rat alpha 1-fetoprotein messenger RNA: 5'-end sequence and glucocorticoid-suppressed liver transcription in an improved nuclear run-off assay.

Authors:  B Turcotte; M Guertin; M Chevrette; L Bélanger
Journal:  Nucleic Acids Res       Date:  1985-04-11       Impact factor: 16.971

7.  c-Ha-ras down regulates the alpha-fetoprotein gene but not the albumin gene in human hepatoma cells.

Authors:  K Nakao; D Lawless; Y Ohe; Y Miyao; H Nakabayashi; H Kamiya; K Miura; E Ohtsuka; T Tamaoki
Journal:  Mol Cell Biol       Date:  1990-04       Impact factor: 4.272

8.  Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine.

Authors:  J M Lemire; N Shiojiri; N Fausto
Journal:  Am J Pathol       Date:  1991-09       Impact factor: 4.307

9.  Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.

Authors:  D Bernier; H Thomassin; D Allard; M Guertin; D Hamel; M Blaquière; M Beauchemin; H LaRue; M Estable-Puig; L Bélanger
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

10.  Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.

Authors:  H Thomassin; D Hamel; D Bernier; M Guertin; L Belanger
Journal:  Nucleic Acids Res       Date:  1992-06-25       Impact factor: 16.971
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