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Literature DB >> 6085818

Disease susceptibility genes and the Ia system.

Abstract

Certain Ia allotypes such as DR4 show a strong association with particular autoimmune diseases such as rheumatoid arthritis. Despite this strong association, a significant number of individuals with the inappropriate Ia allotype develop the disease. It is proposed that these individuals share an Ia determinant or "epitope" with individuals of the appropriate Ia allotype, and that these epitopes, which are "mobile" and can be transmitted from one Ia haplotype and/or gene locus to another by mechanisms such as gene conversion, form the molecular basis for disease-susceptibility genes.

Entities: Disease Gene

Mesh：

Substances：

Year: 1984 PMID： 6085818 DOI： 10.1007/bf00541275

Source DB: PubMed Journal: Rheumatol Int ISSN： 0172-8172 Impact factor: 2.631

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References

16 in total

1. B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

Authors: I F McKenzie; G M Morgan; M S Sandrin; M M Michaelides; R W Melvold; H I Kohn
Journal: J Exp Med Date: 1979-12-01 Impact factor: 14.307

2. Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4.

Authors: S H Lee; P K Gregersen; H H Shen; A Nunez-Roldan; J Silver; R J Winchester
Journal: Rheumatol Int Date: 1984 Impact factor: 2.631

3. Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis.

Authors: R J Duquesnoy; M Marrari; S Hackbarth; A Zeevi
Journal: Hum Immunol Date: 1984-07 Impact factor: 2.850

4. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Authors: D C Shreffler; C S David
Journal: Adv Immunol Date: 1975 Impact factor: 3.543

5. Tryptic peptide comparison of Ia antigen alpha and beta polypeptides from the I-A mutant B6.C-H-2bm12 and its congenic parental strain B6.

Authors: D J McKean; R W Melvold; C David
Journal: Immunogenetics Date: 1981 Impact factor: 2.846

10. Antigen presentation by murine and human cells to a murine T-cell hybridoma: demonstration of a restriction element associated with a major histocompatibility complex class II determinant(s) shared by both species.

Authors: S J Waters; R J Winchester; F Nagase; G J Thorbecke; C A Bona
Journal: Proc Natl Acad Sci U S A Date: 1984-12 Impact factor: 12.779

Disease susceptibility genes and the Ia system.

1. B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

2. Strong association of rheumatoid arthritis with the presence of a polymorphic Ia epitope defined by a monoclonal antibody: comparison with the allodeterminant DR4.

3. Serological and cellular definition of a new HLA-DR associated determinant, MC1, and its association with rheumatoid arthritis.

4. The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

5. Tryptic peptide comparison of Ia antigen alpha and beta polypeptides from the I-A mutant B6.C-H-2bm12 and its congenic parental strain B6.

6. Murine Ia and human DR antigens: homology of amino-terminal sequences.

7. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis.

8. A potential donor gene for the bm1 gene conversion event in the C57BL mouse.

9. The Eb beta gene may have acted as the donor gene in a gene conversion-like event generating the Abm 12 beta mutant.

10. Antigen presentation by murine and human cells to a murine T-cell hybridoma: demonstration of a restriction element associated with a major histocompatibility complex class II determinant(s) shared by both species.