Literature DB >> 6085276

Regulation of intracisternal A particles in mouse teratocarcinoma cells: involvement of DNA methylation in transcriptional control.

F Hojman-Montes de Oca, J Lasneret, L Dianoux, M Canivet, R Ravicovitch-Ravier, J Périès.   

Abstract

The methylation state of Intracisternal A Particle (IAP) genes in mouse teratocarcinoma cell lines has been investigated as an approach to study the regulation of the expression of these particles. Treatment of the cells with the methylation inhibitor 5-azacytidine induces the production of the particles in all the cells; the induction is particularly striking in an embryonal carcinoma cell line which is normally devoid of IAPs. The induction is accompanied by decrease in DNA methylation as demonstrated by using the methylation sensitive isoschizomer enzymes MspI and HpaII. Hypomethylation of the IAP genes correlates with accumulation of IAP, specific polyadenylated RNA reinforcing the hypothesis that methylation plays an important role in the control of IAP expression.

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Year:  1984        PMID： 6085276     DOI： 10.1111/j.1768-322x.1985.tb00337.x

Source DB:  PubMed          Journal:  Biol Cell        ISSN： 0248-4900            Impact factor:   4.458


  11 in total

1.  Tissue and strain-specific patterns of endogenous proviral hypomethylation analyzed by two-dimensional gel electrophoresis.

Authors:  J A Mietz; E L Kuff
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

2.  Selective activation of a discrete family of endogenous proviral elements in normal BALB/c lymphocytes.

Authors:  J A Mietz; J W Fewell; E L Kuff
Journal:  Mol Cell Biol       Date:  1992-01       Impact factor: 4.272

3.  CpG methylation directly regulates transcriptional activity of the human endogenous retrovirus family HERV-K(HML-2).

Authors:  Laurence Lavie; Milena Kitova; Esther Maldener; Eckart Meese; Jens Mayer
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

4.  RNA expression microarray analysis in mouse prospermatogonia: identification of candidate epigenetic modifiers.

Authors:  Christophe Lefèvre; Jeffrey R Mann
Journal:  Dev Dyn       Date:  2008-04       Impact factor: 3.780

5.  In vitro methylation inhibits the promotor activity of a cloned intracisternal A-particle LTR.

Authors:  A Feenstra; J Fewell; K Lueders; E Kuff
Journal:  Nucleic Acids Res       Date:  1986-05-27       Impact factor: 16.971

6.  Epigenetic regulation of an IAP retrotransposon in the aging mouse: progressive demethylation and de-silencing of the element by its repetitive induction.

Authors:  Willy Barbot; Anne Dupressoir; Vladimir Lazar; Thierry Heidmann
Journal:  Nucleic Acids Res       Date:  2002-06-01       Impact factor: 16.971

7.  Germ line-specific expression of intracisternal A-particle retrotransposons in transgenic mice.

Authors:  A Dupressoir; T Heidmann
Journal:  Mol Cell Biol       Date:  1996-08       Impact factor: 4.272

8.  Structure and expression of mobile ETnII retroelements and their coding-competent MusD relatives in the mouse.

Authors:  Corinna Baust; Liane Gagnier; Greg J Baillie; Muriel J Harris; Diana M Juriloff; Dixie L Mager
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

Review 9.  Friend or Foe: Epigenetic Regulation of Retrotransposons in Mammalian Oogenesis and Early Development.

Authors:  Alexei V Evsikov; Caralina Marín de Evsikova
Journal:  Yale J Biol Med       Date:  2016-12-23

10.  Selective expression of intracisternal A-particle genes in established mouse plasmacytomas.

Authors:  K K Lueders; J W Fewell; V E Morozov; E L Kuff
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 5.069
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