Literature DB >> 6083755

Kinetics of the interaction of monophosphates of the antiviral nucleosides 2'-fluoro-1-beta-D-arabinofuranosylpyrimidine and (E)-5-(2-bromovinyl)-2'-deoxyuridine with thymidylate kinases from Vero cells and herpes simplex virus types 1 and 2.

M S Chen, L A Amico, D J Speelman.   

Abstract

The affinities of the monophosphates of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosyluracil and its 5-methyl analog for cellular thymidylate kinase were two or more orders of magnitude greater than for the thymidine-thymidylate kinases from herpes simplex virus types 1 and 2. In contrast, the monophosphate of (E)-5-(2-bromovinyl)-2'-deoxyuridine was found to have a higher affinity for the viral enzymes than for the cellular enzyme.

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Year:  1984        PMID： 6083755      PMCID： PMC180014          DOI： 10.1128/AAC.26.5.778

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.

Authors:  M S Chen; J Walker; W H Prusoff
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

2.  Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine.

Authors:  G B Elion; P A Furman; J A Fyfe; P de Miranda; L Beauchamp; H J Schaeffer
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

3.  Association of thymidylate kinase activity with pyrimidine deoxyribonucleoside kinase induced by herpes simplex virus.

Authors:  M S Chen; W H Prusoff
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

4.  Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.

Authors:  K A Watanabe; U Reichman; K Hirota; C Lopez; J J Fox
Journal:  J Med Chem       Date:  1979-01       Impact factor: 7.446

5.  Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

Authors:  P A Furman; M H St Clair; J A Fyfe; J L Rideout; P M Keller; G B Elion
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

6.  Deoxythymidine kinase induced in HeLa TK- cells by herpes simplex virus type I and type II. II. Purification and characterization.

Authors:  Y C Cheng; M Ostrander
Journal:  J Biol Chem       Date:  1976-05-10       Impact factor: 5.157

7.  Photochemical studies and ultraviolet sensitization of Escherichia coli thymidylate kinase by various halogenated substrate analogs.

Authors:  M S Chen; P K Chang; W H Prusoff
Journal:  J Biol Chem       Date:  1976-11-10       Impact factor: 5.157

8.  (E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent.

Authors:  E De Clercq; J Descamps; P De Somer; P J Barr; A S Jones; R T Walker
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

9.  Therapeutic activities of 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine and -thymine alone and in combination with acyclovir and vidarabine in mice infected intracerebrally with herpes simplex virus.

Authors:  R F Schinazi; J Peters; M K Sokol; A J Nahmias
Journal:  Antimicrob Agents Chemother       Date:  1983-07       Impact factor: 5.191

10.  Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

Authors:  K B Frank; J F Chiou; Y C Cheng
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157
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  8 in total

1.  A mouse model for X-linked adrenoleukodystrophy.

Authors:  J F Lu; A M Lawler; P A Watkins; J M Powers; A B Moser; H W Moser; K D Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

2.  Drug resistance patterns of herpes simplex virus isolates from patients treated with acyclovir.

Authors:  C McLaren; M S Chen; I Ghazzouli; R Saral; W H Burns
Journal:  Antimicrob Agents Chemother       Date:  1985-12       Impact factor: 5.191

3.  Activities of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine and its metabolites against herpes simplex virus types 1 and 2 in cell culture and in mice infected intracerebrally with herpes simplex virus type 2.

Authors:  R F Schinazi; J J Fox; K A Watanabe; A J Nahmias
Journal:  Antimicrob Agents Chemother       Date:  1986-01       Impact factor: 5.191

4.  Targeting of an inducible toxic phenotype in animal cells.

Authors:  E Borrelli; R Heyman; M Hsi; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

5.  Effects of various nucleosides on antiviral activity and metabolism of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil against herpes simplex virus types 1 and 2.

Authors:  T Suzutani; H Machida; T Sakuma; M Azuma
Journal:  Antimicrob Agents Chemother       Date:  1988-10       Impact factor: 5.191

6.  Characterization of Streptococcus pneumoniae thymidylate kinase: steady-state kinetics of the forward reaction and isothermal titration calorimetry.

Authors:  Chantal M Petit; Kristin K Koretke
Journal:  Biochem J       Date:  2002-05-01       Impact factor: 3.857

7.  Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Authors:  P A Furman; J A Fyfe; M H St Clair; K Weinhold; J L Rideout; G A Freeman; S N Lehrman; D P Bolognesi; S Broder; H Mitsuya
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

8.  Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.

Authors:  L Cui; S Yoon; R F Schinazi; J P Sommadossi
Journal:  J Clin Invest       Date:  1995-02       Impact factor: 14.808
  8 in total

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