Literature DB >> 6083453

Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing.

H Nawa, H Kotani, S Nakanishi.   

Abstract

A novel mammalian neuropeptide, the tachykinin substance K, is specified by a discrete genomic segment. Alternative RNA splicing generates two distinct mRNAs encoding the neuropeptide substance P alone or with substance K from a single preprotachykinin gene. Relative amounts of the mRNAs vary in different tissues, suggesting that the substance K-encoding sequence is regulated in a tissue-specific manner.

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Year:  1984        PMID： 6083453     DOI： 10.1038/312729a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  68 in total

1.  Loss of cannabinoid CB(1) receptors in the basal ganglia in the late akinetic phase of rats with experimental Huntington's disease.

Authors:  Isabel Lastres-Becker; María Gómez; Rosario De Miguel; José A. Ramos; Javier Fernández-Ruiz
Journal:  Neurotox Res       Date:  2002 Nov-Dec       Impact factor: 3.911

2.  Characterization of the endokinins: human tachykinins with cardiovascular activity.

Authors:  Nigel M Page; Nicola J Bell; Sheila M Gardiner; Isaac T Manyonda; Kerensa J Brayley; Philip G Strange; Philip J Lowry
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-25       Impact factor: 11.205

Review 3.  Tachykinins and excitotoxicity in cerebellar granule cells.

Authors:  Cinzia Severini; Cristina Zona
Journal:  Cerebellum       Date:  2006       Impact factor: 3.847

4.  Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A.

Authors:  J E Krause; J M Chirgwin; M S Carter; Z S Xu; A D Hershey
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

5.  The memory gene dunce+ encodes a remarkable set of RNAs with internal heterogeneity.

Authors:  R L Davis; N Davidson
Journal:  Mol Cell Biol       Date:  1986-05       Impact factor: 4.272

6.  Identification of chromosome 7 inversion breakpoints in an autistic family narrows candidate region for autism susceptibility.

Authors:  Holly N Cukier; David A Skaar; Melissa Y Rayner-Evans; Ioanna Konidari; Patrice L Whitehead; James M Jaworski; Michael L Cuccaro; Margaret A Pericak-Vance; John R Gilbert
Journal:  Autism Res       Date:  2009-10       Impact factor: 5.216

Review 7.  The Jeremiah Metzger Lecture. From POMC to functional diversity of neural peptides: the key importance of convertases.

Authors:  M Chretien; L Gasper; S Benjannet; M Mbikay; C Lazure; N G Seidah
Journal:  Trans Am Clin Climatol Assoc       Date:  1991

8.  The distribution and origin of nerve fibers immunoreactive for substance P and neurokinin A in the anterior buccal gland of the rat.

Authors:  J Törnwall; H Uusitalo; Y T Konttinen
Journal:  Cell Tissue Res       Date:  1994-08       Impact factor: 5.249

9.  Development of substance P and neurokinin A immunoreactivity in ganglia supplying nerves to the submandibular glands of the rat.

Authors:  E Virta; H Uusitalo
Journal:  Histochemistry       Date:  1993-10

10.  Neurokinin A is the predominant tachykinin in human bronchoalveolar lavage fluid in normal and asthmatic subjects.

Authors:  L G Heaney; L J Cross; L P McGarvey; K D Buchanan; M Ennis; C Shaw
Journal:  Thorax       Date:  1998-05       Impact factor: 9.139
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