Comparative morphological and cytogenetical investigations on human ovarian granulosa cell tumors.

Comparative morphological and cytogenetical investigations of three granulosa cell tumors revealed the existence of two distinct categories which represent two morphocytogenetical stages of tumor progression. The following peculiarities characterized them: 1) In the premalignant stage the microfollicular and macrofollicular patterns with Call-Exner body like structures are prevailing and besides normal diploid metaphases some neardiploid are found. 2) In the malignant stage following the occurence and gradual selection of a neartriploid neoplastic cell type undifferentiated sarcomatous aspects are dominant.