Literature DB >> 607500

Keratolytic winter erythema or 'oudtshoorn skin': a newly recognized inherited dermatosis prevalent in South Africa.

G H Findlay, G T Nurse, T Heyl, P R Hull, T Jenkins, H Klevansky, J G Morrison, J Sher, E J Schulz, E Swart, I J Venter, D A Whiting.   

Abstract

A hitherto undescribed inherited dermatosis, traceable to certain 19th-century inhabitants of Oudtshoorn, CP, has been transmitted as an autosomal dominant to a large number of their present-day descendants. The disease consists of intermittent and recurrent centrifugal peeling, with redness, of the palms and soles in particular. In more severe cases similar patches are found extending up the limbs to the buttocks and the trunk generally. The inconvenience is usually moderate, but it may be incapacitating. Some temporary relief, but so far nothing permanent, can be offered through treatment.

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Year:  1977        PMID: 607500

Source DB:  PubMed          Journal:  S Afr Med J


  4 in total

Review 1.  Medical genetics in South Africa.

Authors:  T Jenkins
Journal:  J Med Genet       Date:  1990-12       Impact factor: 6.318

2.  Localization of the gene causing keratolytic winter erythema to chromosome 8p22-p23, and evidence for a founder effect in South African Afrikaans-speakers.

Authors:  M Starfield; H C Hennies; M Jung; T Jenkins; T Wienker; P Hull; A Spurdle; W Küster; M Ramsay; A Reis
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

3.  Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.

Authors:  Thandiswa Ngcungcu; Martin Oti; Jan C Sitek; Bjørn I Haukanes; Bolan Linghu; Robert Bruccoleri; Tomasz Stokowy; Edward J Oakeley; Fan Yang; Jiang Zhu; Marc Sultan; Joost Schalkwijk; Ivonne M J J van Vlijmen-Willems; Charlotte von der Lippe; Han G Brunner; Kari M Ersland; Wayne Grayson; Stine Buechmann-Moller; Olav Sundnes; Nanguneri Nirmala; Thomas M Morgan; Hans van Bokhoven; Vidar M Steen; Peter R Hull; Joseph Szustakowski; Frank Staedtler; Huiqing Zhou; Torunn Fiskerstrand; Michele Ramsay
Journal:  Am J Hum Genet       Date:  2017-04-27       Impact factor: 11.025

Review 4.  Keratolytic Winter Erythema: An Update.

Authors:  Michèle Ramsay; Thandiswa Ngcungcu; Wayne Grayson
Journal:  Dermatopathology (Basel)       Date:  2019-06-26
  4 in total

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