DNA-dependent formation of the synaptinemal complex at meiotic prophase.

EVALAUTION OF MICROSPOROCYTES CULTURED DURING DISCRETE PERIODS OF MEIOTIC PROPHASE IN THE PRESENCE OF DEOXYADENOSINE, AN INHIBITOR OF DNA SYNTHESIS, INDICATE THAT: (1) late leptonema or early zygonema DNA synthesis is required to initiate the formation of the synaptinemal complex; (2) DNA synthesized during late zygonema is necessary for the disjunction of the paired homologs at diplonema; and (3) DNA synthesis in pachynema is a requisite for normal anaphase II separation of sister chromatids.