Literature DB >> 6058345

Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz[a]anthracene.

T Sugiyama, Y Kurita, Y Nishizuka.   

Abstract

A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.

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Year:  1967        PMID: 6058345     DOI: 10.1126/science.158.3804.1058

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  14 in total

1.  Cellular DNA regions involved in the induction of rat thymic lymphomas (Mlvi-1, Mlvi-2, Mlvi-3, and c-myc) represent independent loci as determined by their chromosomal map location in the rat.

Authors:  P N Tsichlis; M A Lohse; C Szpirer; J Szpirer; G Levan
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

2.  Experimental alteration of the phenotype of animal cells in vivo.

Authors:  C B Huggins
Journal:  J Clin Pathol Suppl (R Coll Pathol)       Date:  1974

3.  Effects of polycyclic hydrocarbons on the induction of chromosomal aberrations in absence of an exogenous metabolic activation system in cultured hamster cells.

Authors:  T S Kochhar
Journal:  Experientia       Date:  1982-07-15

4.  Establishment and characterization of cell lines from the Walker carcinoma 256 able to grow in suspension culture and deficient in thymidine kinase.

Authors:  F Arvelo; A Yabrudi; M E Delgado; N González-Cadavid
Journal:  In Vitro       Date:  1984-07

Review 5.  [Chromosomal abnormalities in human neoplasia (author's transl)].

Authors:  C R Bartram; H W Rüdiger
Journal:  Klin Wochenschr       Date:  1978-08-01

6.  Changes in chromosomes of bone marrow after intravenous injections of 7,12-dimethylbenz(a)anthracene and related compounds.

Authors:  E D Rees; S K Majumdar; A Shuck
Journal:  Proc Natl Acad Sci U S A       Date:  1970-08       Impact factor: 11.205

7.  Role of erythropoietin in 7,12-dimethylbenz(a)anthracene induction of acute chromosome aberration and leukemia in the rat.

Authors:  T Sugiyama
Journal:  Proc Natl Acad Sci U S A       Date:  1971-11       Impact factor: 11.205

8.  Chromosomal changes in cell lines from mouse tumors induced by nickel sulfide and methylcholanthrene.

Authors:  N T Christie; D M Tummolo; N W Biggart; E C Murphy
Journal:  Cell Biol Toxicol       Date:  1988-12       Impact factor: 6.691

9.  Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.

Authors:  R Dofuku; J L Biedler; B A Spengler; L J Old
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

10.  Nonrandom chromosomal abnormalities in hematologic disorders of man.

Authors:  J D Rowley
Journal:  Proc Natl Acad Sci U S A       Date:  1975-01       Impact factor: 11.205

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