Literature DB >> 605351

Humoral and cell-mediated immunity to hepatitis B virus antigens in acute and chronic liver disease.

J Aldershvile, O Dietrichson, F Hardt, J O Nielsen, P Skinhöj.   

Abstract

The humoral immune response to hepatitis B virus antigens and the cell-mediated immunity to hepatitis B surface antigen (HBsAg) were investigated in 12 healthy persons and 56 patients with various liver diseases. In patients with acute viral hepatitis type B, anti-hepatitis B core antigen was present constantly in serum in all phases, and after clinical recovery simultaneously with anti-HBs. A transitory cellular immune response to HBsAg was demonstrated at the time the antigen was cleared, while a patient with persisting HBs antigenaemia and another with transient hepatitis Bc antigen showed no response during the course of the disease. Cellular immune response to HBsAg was present only infrequently in patients with chronic liver disease type B and non-B, thus suggesting that a cellular immunity to HBsAg is not a prerequisite for the development of these conditions.

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Year:  1977        PMID： 605351     DOI： 10.3109/00365527709181350

Source DB:  PubMed          Journal:  Scand J Gastroenterol        ISSN： 0036-5521            Impact factor:   2.423


  10 in total

1.  Immune response to purified non-A, non-B hepatitis-related antigen demonstrated by leukocyte migration inhibition in patients recovering from the infection.

Authors:  A Nicole; O Spertini; D Lavanchy; P C Frei
Journal:  Infection       Date:  1986 Jan-Feb       Impact factor: 3.553

2.  Isolation of Mallory bodies and an attempt to demonstrate cell mediated immunity to Mallory body isolate in patients with alcoholic liver disease.

Authors:  C Gluud; F Hardt; J Aldershvile; P Christoffersen; H Lyon; J Nielsen
Journal:  J Clin Pathol       Date:  1981-09       Impact factor: 3.411

3.  Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.

Authors:  G M Dusheiko; J H Hoofnagle; W G Cooksley; S P James; E A Jones
Journal:  J Clin Invest       Date:  1983-05       Impact factor: 14.808

4.  Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection.

Authors:  Priscilla L Yang; Alana Althage; Josan Chung; Francis V Chisari
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-08       Impact factor: 11.205

5.  The HBsAg-Positive Patient: Implications and a Guide to Management.

Authors:  R P Larke
Journal:  Can Fam Physician       Date:  1979-03       Impact factor: 3.275

6.  Influence of (+)-cyanidanol-3 on the leukocyte migration inhibition test carried out in the presence of purified protein derivative and hepatitis B surface antigen.

Authors:  J J Vallotton; P C Frei
Journal:  Infect Immun       Date:  1981-05       Impact factor: 3.441

7.  Effects of interferon and adenine arabinoside treatment of hepatitis B virus infection on cellular immune responses.

Authors:  B Hafkin; R B Pollard; M L Tiku; W S Robinson; T C Merigan
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

8.  Cell-mediated immunity to hepatitis B surface antigen in man.

Authors:  R G Hanson; J H Hoofnagle; G Y Minuk; R H Purcell; J L Gerin
Journal:  Clin Exp Immunol       Date:  1984-08       Impact factor: 4.330

9.  Immune response to hepatitis B virus surface antigen peptides during HBV infection.

Authors:  A Mishra; H Durgapal; V Manivel; S K Acharya; K V Rao; S K Panda
Journal:  Clin Exp Immunol       Date:  1992-11       Impact factor: 4.330

10.  Selective sensitization of peripheral blood T lymphocytes to hepatitis B core antigen in patients with chronic active hepatitis type B.

Authors:  C Ferrari; A Penna; P Sansoni; T Giuberti; T M Neri; F V Chisari; F Fiaccadori
Journal:  Clin Exp Immunol       Date:  1986-12       Impact factor: 4.330
  10 in total

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