Literature DB >> 604166

Properties of equilibria in multi-locus genetic systems.

W J Ewens, G Thomson.   

Abstract

The classical mathematical theory of population genetics considered, for simplicity, almost exclusively one-locus systems. In the last two decades much work has been done on two-locus and, less frequently, multi-locus systems. This research has usually involved investigating properties of systems with given, and usually rather special, fitness parameters. Real genetic fitness systems are undoubtedly multi-locus and seldom will possess simplifying characteristics. One aim of this paper is to study generalized systems where no special assumptions are made about fitness structure, the number of alleles at each locus, the number of loci involved or the recombination structure between loci. A second aim is to consider marginal properties (often one-locus properties) of complex systems: the fact that many observations involve data from only on locus makes this second aim relevant.

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Year:  1977        PMID: 604166      PMCID: PMC1213778     

Source DB:  PubMed          Journal:  Genetics        ISSN: 0016-6731            Impact factor:   4.562


  8 in total

1.  Numerical studies on two-loci selection models with general viabilities.

Authors:  S Karlin; D Carmelli
Journal:  Theor Popul Biol       Date:  1975-06       Impact factor: 1.570

2.  General two-locus selection models: some objectives, results and interpretations.

Authors:  S Karlin
Journal:  Theor Popul Biol       Date:  1975-06       Impact factor: 1.570

3.  ON THE NONEXISTENCE OF ADAPTIVE TOPOGRAPHIES.

Authors:  P A MORAN
Journal:  Ann Hum Genet       Date:  1964-06       Impact factor: 1.670

4.  Attainment of Quasi Linkage Equilibrium When Gene Frequencies Are Changing by Natural Selection.

Authors:  M Kimura
Journal:  Genetics       Date:  1965-11       Impact factor: 4.562

5.  THE BALANCE, THE STEELYARD AND THE CONCEPT OF FORCE.

Authors:  W J Fisher
Journal:  Science       Date:  1918-11-01       Impact factor: 47.728

6.  Remarks on the evolutionary effect of natural selection.

Authors:  W J Ewens
Journal:  Genetics       Date:  1976-07       Impact factor: 4.562

7.  The evolution of one- and two-locus systems.

Authors:  T Nagylaki
Journal:  Genetics       Date:  1976-07       Impact factor: 4.562

8.  Genetics of Zoarces populations. VI. Further evidence, based on age group samples, of a heterozygote deficit in the EstIII polymorphism.

Authors:  F B Christiansen; O Frydenberg; A O Gyldenholm; V Simonsen
Journal:  Hereditas       Date:  1974       Impact factor: 3.271

  8 in total
  12 in total

1.  Fundamental theorem of natural selection under gene-culture transmission.

Authors:  C S Findlay
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  Marginal underdominance at a stable equilibrium.

Authors:  A Hastings
Journal:  Proc Natl Acad Sci U S A       Date:  1981-10       Impact factor: 11.205

3.  Rate of evolution of a character without epistasis.

Authors:  T Nagylaki
Journal:  Proc Natl Acad Sci U S A       Date:  1989-03       Impact factor: 11.205

4.  Unexpected behavior in two locus genetic systems: an analysis of marginal underdominance at a stable equilibrium.

Authors:  A Hastings
Journal:  Genetics       Date:  1982-09       Impact factor: 4.562

5.  Moments, cumulants, and polygenic dynamics.

Authors:  R Bürger
Journal:  J Math Biol       Date:  1991       Impact factor: 2.259

6.  Disequilibrium in two-locus mutation-selection balance models.

Authors:  A Hastings
Journal:  Genetics       Date:  1988-03       Impact factor: 4.562

7.  Linkage disequilibrium and genetic variances under mutation-selection balance.

Authors:  A Hastings
Journal:  Genetics       Date:  1989-04       Impact factor: 4.562

8.  Multilocus population genetics with weak epistasis. I. Equilibrium properties of two-locus two-allele models.

Authors:  A Hastings
Journal:  Genetics       Date:  1985-04       Impact factor: 4.562

9.  Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.

Authors:  S Gavrilets; G de Jong
Journal:  Genetics       Date:  1993-06       Impact factor: 4.562

10.  Disequilibrium, selection, and recombination: limits in two-locus, two-allele models.

Authors:  A Hastings
Journal:  Genetics       Date:  1981-07       Impact factor: 4.562

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