| Literature DB >> 6038694 |
Abstract
Infection with Friend leukemia virus causes a marked increase in the activity of splenic phosphoribosylamidotransferase in mice. Intraperitoneal injection of purine nucleotides and their free bases inhibits this enzyme. This is the first example of the control of phosphoribosylamidostransferase in vivo in the mammalian system as well as in virus-induced leukemia. Experiments in vitro support the findings in vivo.Entities:
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Year: 1967 PMID： 6038694 DOI： 10.1126/science.157.3793.1203
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728